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Forschungsdatenbank PMU-SQQUID

A high-glucose diet affects Achilles tendon healing in rats.
Korntner, S; Kunkel, N; Lehner, C; Gehwolf, R; Wagner, A; Augat, P; Stephan, D; Heu, V; Bauer, HC; Traweger, A; Tempfer, H;
Sci Rep. 2017; 7(1): 780
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Augat Peter
Bauer Hans Christian
Gehwolf Renate
Heu Verena
Korntner Stefanie
Kunkel Nadja
Lehner Christine
Stephan Daniel
Tempfer Herbert
Traweger Andreas
Wagner Andrea

Abstract

Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively. Compared to the control group, tendon repair tissue thickness and stiffness were increased in the high-glucose group after 2 weeks and gait pattern was altered after 1 and 2 weeks. Cell proliferation was up to 3-fold higher and the expression of the chondrogenic marker genes Sox9, Col2a1, Acan and Comp was significantly increased 2 and 4 weeks post-surgery. Further, a moderate increase in cartilage-like areas within the repair tissue was evident after 4 weeks of a high-glucose diet regimen. In summary, we propose that a high-glucose diet significantly affects tendon healing after injury in non-diabetic rats, potentially driving chondrogenic degeneration.