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Cortical afferent inhibition reflects cognitive impairment in obstructive sleep apnea syndrome: a TMS study.
Nardone, R; Bergmann, J; Brigo, F; Höller, Y; Schwenker, K; Florea, C; Kunz, AB; Golaszewski, S; Trinka, E;
Sleep Med. 2016; 24:51-56
Originalarbeiten (Zeitschrift)


Bergmann Jürgen
Golaszewski Stefan
Höller Yvonne
Nardone Raffaele
Schwenker Kerstin
Trinka Eugen


Patients with obstructive sleep apnea syndrome (OSAS) show neurocognitive impairment, but the exact mechanisms that cause cognitive dysfunctions remain unknown. The cholinergic system is known to play a key role in all attentional processes and cognitive functions. A transcranial magnetic stimulation (TMS) protocol may give direct information about the function of some cholinergic circuits in the human brain; this technique relies on short latency afferent inhibition (SAI) of the motor cortex. The objective of this exploratory study was to test the hypothesis that impaired cognitive performances in OSAS patients are associated with a dysfunction of the cholinergic system, as assessed by SAI.

Useful keywords (using NLM MeSH Indexing)

Afferent Pathways/physiology*

Cholinergic Fibers

Cognitive Dysfunction/physiopathology*



Middle Aged

Neural Inhibition/physiology*

Neuropsychological Tests

Sleep Apnea, Obstructive/complications*

Transcranial Magnetic Stimulation*

Find related publications in this database (Keywords)

Obstructive sleep apnea syndrome
Cognitive impairment
Neuropsychological tests
Transcranial magnetic stimulation
Short latency afferent inhibition