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Forschungsdatenbank PMU-SQQUID

The Salzburg concept of intraoperative radiotherapy for breast cancer: results and considerations.
Reitsamer, R; Sedlmayer, F; Kopp, M; Kametriser, G; Menzel, C; Deutschmann, H; Nairz, O; Hitzl, W; Peintinger, F;
Int J Cancer. 2006; 118(11):2882-2887
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Deutschmann Heinz
Hitzl Wolfgang
Kopp Michael
Menzel Christian
Peintinger Florentia
Reitsamer Roland
Sedlmayer Felix

Abstract

Aim of this study is to show that ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery can be reduced by proper surgery and modern radiotherapy techniques. Three hundred and seventy eight women with stage I or II breast cancer had breast conserving surgery and received 51-56.1 Gy of postoperative radiation to the whole breast in 1.7 Gy fractions, but patients received different boost strategies. Group 1 (n = 188) received electron boost radiation of 12 Gy subsequent to the irradiation to the whole breast, group 2 (n = 190) received intraoperative electron boost radiation of 9 Gy directly to the tumor bed, followed by whole breast irradiation. After a median follow up period of 81.0 months in group 1 and a median follow up period of 51.1 months in group 2, 12 IBTRs (6.4%) could be observed in group 1 and no IBTR could be observed in group 2 (0.0%). The 5-year actuarial rates of IBTR were 4.3% (95% CI, 1.9-8.3%) and 0.0% (95% CI, 0.0-1.9%), respectively (p = 0.0018). The 5-year actuarial rates of distant recurrence were 8.6% (95% CI, 4.9-13.5%) and 4.2% (95% CI, 1.8-8.2%), respectively (p = 0.08). The 5 year disease-free survival rates were 90.9% (95% CI, 85.8-94.7%) in group 1 and 95.8% (95% CI, 91.8-98.2%) in group 2 (p = 0.064). Immediate IORT-boost and whole breast irradiation yields excellent local control at 5 years, and was associated with a statistically significant decreased rate of IBTR compared with a similar cohort of patients treated with whole breast irradiation and conventional electron boost.


Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Aged, 80 and over

Breast Neoplasms/pathology

Breast Neoplasms/radiotherapy*

Breast Neoplasms/surgery*

Disease-Free Survival

Electrons

Female

Functional Laterality

Humans

Intraoperative Care

Mastectomy, Segmental*

Middle Aged

Neoplasm Recurrence, Local/prevention*

control*

Neoplasm Staging

Treatment Outcome


Find related publications in this database (Keywords)

intraoperative radiotherapy
breast cancer
breast conserving surgery
boost radiation