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Forschungsdatenbank PMU-SQQUID

Relationship between thrombin generation and carotid intima-media thickness.
Bernhard, H; Wipfler, P; Leschnik, B; Novak, M; Kraus, J; Pilz, G; Ladurner, G; Muntean, W;
HAMOSTASEOLOGIE. 2010; 30 Suppl 1: S168-S171.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Kraus Jörg
Pilz Georg
Wipfler Peter

Abstract

Increasing evidence indicates that thrombin plays a role not only in thrombosis but also in the progression of atherosclerosis. Aim: The relationship between thrombin generation and intima-media thickness (IMT) as an index of subclinical atherosclerosis was investigated. Participants, material, methods: We examined 163 asymptomatic middle-aged persons free of overt clinical atherosclerotic disease. They underwent ultrasonography of the common carotid arteries. In addition, thrombin generation was measured by means of CAT (calibrated automated thrombography). For our study we divided the healthy study participants into three age groups (< 45, 45-60 and > 60 years). Results: A significant positive correlation was seen between endogenous thrombin potential (ETP) (p = 0.012), time to peak (TTP) (p = 0.033) start tail (p = 0.007) and carotid IMT in the group of healthy volunteers younger than 45 years. Conclusion: We demonstrated that in adults younger than 45 years without clinically overt atherosclerotic disease ETP was significantly associated with carotid IMT. It is tempting to speculate that ETP may serve as an index for subclinical atherosclerosis in persons below 45 years.


Useful keywords (using NLM MeSH Indexing)

Adult

Atherosclerosis/metabolism

Carotid Artery, Common/metabolism

Humans

Middle Aged

Platelet Count

Reference Values

Thrombin/biosynthesis

Thrombin/metabolism*

Thrombosis/metabolism

Tunica Intima/metabolism

Tunica Intima/ultrasonography*

Tunica Media/metabolism

Tunica Media/ultrasonography*


Find related publications in this database (Keywords)

Calibrated automated thrombography
endogenous thrombin potential
intima-media thickness