' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

Cytokine and growth factor concentration in cerebrospinal fluid from patients with hydrocephalus following endovascular embolization of unruptured aneurysms in comparison with other types of hydrocephalus.
Killer, M; Arthur, A; Al-Schameri, AR; Barr, J; Elbert, D; Ladurner, G; Shum, J; Cruise, G;
Neurochem Res. 2010; 35(10):1652-1658
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Al-Schameri Abdul Rahman
Killer-Oberpfalzer Monika

Abstract

To better understand the development of hydrocephalus of different origins, we evaluated cytokine and growth factor concentration in cerebrospinal fluid from patients with hydrocephalus. CSF was collected from patients developing hydrocephalus following hemorrhage (n = 15), patients with normal pressure hydrocephalus (n = 10), and following the embolization of unruptured intracranial aneurysms (n = 9). Myelography patients (n = 15) served as controls. Quantification of 11 molecules relating angiogenesis, inflammation, and wound healing in the CSF was performed using ELISA. All three hydrocephalus groups had decreased concentration of TIMP-4 compared to the normal group. The hemorrhage group showed increased concentration of IL-6, IL-8, MCP-1, MMP-9, and TIMP-1 compared to the control group. The unruptured aneurysm group had increased concentration of IL-6 and decreased concentration of TIMP-2 compared to the control group. Compared to the normal patients, increased concentrations of wound healing molecules were evident in all three groups. Increased inflammation was evident in the hemorrhage and unruptured aneurysm groups.


Useful keywords (using NLM MeSH Indexing)

Cytokines/cerebrospinal fluid*

Embolization, Therapeutic*

Endovascular Procedures

Enzyme-Linked Immunosorbent Assay

Humans

Hydrocephalus/cerebrospinal fluid*

Hydrocephalus/complications

Hydrocephalus/therapy

Intercellular Signaling Peptides and Proteins/cerebrospinal fluid*

Intracranial Aneurysm/cerebrospinal fluid*

Intracranial Aneurysm/complications

Intracranial Aneurysm/therapy

Subarachnoid Hemorrhage/cerebrospinal fluid

Subarachnoid Hemorrhage/complications

Subarachnoid Hemorrhage/therapy

Ventriculoperitoneal Shunt


Find related publications in this database (Keywords)

CSF
Cytokines
Growth factors
Hydrocephalus
Subarachnoid hemorrhage