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Perampanel for the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy.
Rohracher, A; Brigo, F; Höfler, J; Kalss, G; Neuray, C; Dobesberger, J; Kuchukhidze, G; Leitinger, M; Trinka, E;
Expert Opin Pharmacother. 2016; 17(10):1403-1411
Originalarbeiten (Zeitschrift)


Dobesberger Judith
Höfler Julia
Kalss Gudrun
Kuchukhidze Giorgi
Leitinger Markus
Rohracher Alexandra
Trinka Eugen


The non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) - receptor antagonist perampanel (PER) was approved in 2015 for treatment of primary generalized tonic-clonic seizures (pGTCS). The aim of this narrative review is to summarize available data on pharmacological properties, efficacy and tolerability of PER in pGTCs.
Data sources included MEDLINE, EMBASE, Google Scholar and ClinicalTrials.gov, conference proceedings of the ILAE congresses and the most recent conference proceedings of the American Epilepsy Society (2013 to 2015).
A placebo-controlled clinical phase III study including 164 patients (≥ 12 years) with pGTCS in idiopathic generalized epilepsies (IGE) demonstrated efficacy of PER in reducing pGTCS with good tolerability profile, and without aggravating absence seizures or myoclonic seizures. Dizziness, the main adverse event (AE), can be avoided by bedtime administration. Psychiatric AEs ranging from mild depression to aggression and suicidal attempts should be especially monitored in patients with a history of psychiatric disorders. Co-administration of enzyme inducing antiepileptic drugs (AEDs) might decrease PER plasma levels and make dose adjustment necessary. A reduced efficacy of progesterone-containing oral contraceptives should be considered when administering PER to young women. There is lack of evidence on PER treatment in pregnancy. Although no teratogenic effects were observed in animal models, PER is not recommended for women of childbearing age without contraception.

Useful keywords (using NLM MeSH Indexing)

Anticonvulsants/therapeutic use*

Drug Therapy, Combination

Epilepsy, Generalized/drug therapy*

Epilepsy, Tonic-Clonic/drug therapy


Mental Disorders/complications

Pyridones/therapeutic use*

Receptors, AMPA/antagonists*


Seizures/drug therapy

Treatment Outcome

Find related publications in this database (Keywords)

Idiopathic generalized
primary generalized tonic clonic