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MR atypical Wernicke encephalopathy showing extensive brain stem and diencephalic involvement.
Nardone, R; Venturi, A; Golaszewski, S; Caleri, F; Tezzon, F; Ladurner, G;
J NEUROIMAGING. 2010; 20(2): 204-207.


Golaszewski Stefan
Nardone Raffaele


Wernicke encephalopathy (WE) is a serious neurological disorder caused by thiamine (vitamin B1) deficiency. We report a case of atypical and extensive location of abnormal signal lesions on magnetic resonance imaging (MRI) in a man with alcohol abuse with WE. MRI performed on the first hospital day showed signal intensity alterations extending in the whole brain stem and diencephalon; the mismatch between diffusion-weighted images and apparent diffusion coefficient map was highly suggestive of vasogenic edema. This report further supports the view that WE may represent a spectrum of radiological entities and can have a wide spectrum of manifestations on MRI; thus, clinical features are essential to diagnose it.

Useful keywords (using NLM MeSH Indexing)



Brain Stem/pathology*



Magnetic Resonance Imaging/methods*


Middle Aged

Wernicke Encephalopathy/etiology*

Wernicke Encephalopathy/pathology*

Find related publications in this database (Keywords)

Wernicke encephalopathy
brain stem
magnetic resonance imaging
diffusion-weighted images