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Forschungsdatenbank PMU-SQQUID

Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS).
Huehne, K; Schaal, U; Leis, S; Uebe, S; Gosso, MF; van den Maagdenberg, AM; Maihöfner, C; Birklein, F; Rautenstrauss, B; Winterpacht, A;
Neurosci Lett. 2010; 472(1):19-23
Originalarbeiten (Zeitschrift)


Leis Stefan


Complex regional pain syndrome (CRPS) is a condition that is characterized by severe pain and exaggerated neurogenic inflammation, which may develop after injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) that are released from nociceptors. Genetic factors may play a role in CRPS as was suggested by the occurrence of familial cases and several genetic association studies investigating mainly the human leukocyte antigen (HLA) system. Here we investigated the role of neutral endopeptidase (NEP), a key enzyme in neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of neuropeptides may be a possible pathomechanism in CRPS. To this end, we tested a GT-repeat polymorphism in the NEP promoter region as well as 18 tag-SNPs in six linkage disequilibrium (LD) blocks in the NEP gene region in 320 CRPS patients and 376 controls. No significant genetic association was observed. Thus, we conclude that the NEP gene does not seem to be a major risk factor for CRPS.

Useful keywords (using NLM MeSH Indexing)

5" Flanking Region


Case-Control Studies

Complex Regional Pain Syndromes/genetics*

Dinucleotide Repeats


Genetic Association Studies

Genetic Predisposition to Disease


Linkage Disequilibrium


Middle Aged


Polymorphism, Genetic

Promoter Regions, Genetic

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