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Forschungsdatenbank PMU-SQQUID

[Contribute of functional magnetic resonance imaging to the understanding of psychiatric disorders].
Höller, Y; Kronbichler, M; Zeller, A; Klein, S; Hinterhuber, H; Golaszewski, S; Ladurner, G;
NEUROPSYCHIATRIE. 2009; 23(2): 84-90.
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PMU-Autor/inn/en

Golaszewski Stefan
Höller Yvonne
Kronbichler Martin

Abstract

Contribute of functional magnetic resonance imaging to the understanding of psychiatric disorders Functional magnetic resonance imaging (fMRI) has been shown to be a very useful tool to do research on psychiatric disorders, validating psychotherapeutical interventions, medication as well as disorder-specific deficits. The field of fMRI-research is examining the potential of identifying differences of activity between brains of clinical, subclinical and healthy subjects. The design of such research is drawn to evaluate the average activation to different conditions. We remark that there are still some methodological problems to face, i.e. choosing the sample with special considerations on comorbidity and medication, accounting individual differences in brain activation, complex statistical calculations etc. When evaluating therapeutical interventions it is necessary to take the placebo-effect into account. However, fMRI is a highly promising research method. For future application of fMRI in clinical practice it would be worth building standard paradigms. Then, valid diagnostics of impaired functionality may be possible. Furthermore, fMRI should be combined with other neurodiagnostical technologies and with genetics. The cooperation of different fields in brain research with fMRI may provide further knowledge about psychiatric disorders.


Useful keywords (using NLM MeSH Indexing)

Brain/drug effects

Brain/physiopathology*

Controlled Clinical Trials as Topic

Humans

Magnetic Resonance Imaging*

Mental Disorders/diagnosis

Mental Disorders/physiopathology*

Mental Disorders/therapy

Oxygen Consumption/drug effects

Oxygen Consumption/physiology

Placebo Effect

Psychotherapy

Psychotropic Drugs/adverse effects

Psychotropic Drugs/therapeutic use


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