PMU-Autor/inn/en
Golaszewski StefanAbstract
Canine degenerative myelopathy (CDM) represents a unique naturally occurring animal model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs, neuropathologic findings, and involvement of the superoxide dismutase 1 (SOD1) mutation. A definitive diagnosis can only be made postmortem through microscopic detection of axonal degeneration, demyelination and astroglial proliferation, which is more severe in the dorsal columns of the thoracic spinal cord and in the dorsal portion of the lateral funiculus. Interestingly, the muscle acetylcholine receptor complexes are intact in CDM prior to functional impairment, thus suggesting that muscle atrophy in CDM does not result from physical denervation. Moreover, since sensory involvement seems to play an important role in CDM progression, a more careful investigation of the sensory pathology in ALS is also warranted. The importance of SOD1 expression remains unclear, while oxidative stress and denatured ubiquinated proteins appear to play a crucial role in the pathogenesis of CDM. In this updated narrative review we performed a systematic search of the published studies on CDM that may shed light on the pathophysiological mechanisms of human ALS. A better understanding of the factors that determine the disease progression in CDM may be beneficial for the development of effective treatments for ALS.
Useful keywords (using NLM MeSH Indexing)
Amyotrophic Lateral Sclerosis/diagnosis
Amyotrophic Lateral Sclerosis/etiology*
Amyotrophic Lateral Sclerosis/genetics
Amyotrophic Lateral Sclerosis/pathology*
Animals
Disease Models, Animal*
Dogs*
Humans
Spinal Cord/pathology
Spinal Cord Diseases/genetics
Spinal Cord Diseases/pathology
Spinal Cord Diseases/veterinary
Superoxide Dismutase/genetics
Superoxide Dismutase/metabolism
Find related publications in this database (Keywords)
Canine degenerative myelopathy