PMU-Autor/inn/en
Lehner ChristineAbstract
The choroid plexus (CP) is rich in barrier mechanisms including transporters and enzymes which can influence drug disposition between blood and brain. We have limited knowledge of their state in fetus. We have studied barrier mechanisms along with metabolism and transporters influencing xenobiotics, using RNAseq and protein analysis, in the CP during the second-half of gestation in a nonhuman primate (Papio hamadryas). There were no differences in the expression of the tight-junctions at the CP suggesting a well-formed fetal blood-CSF barrier during this period of gestation. Further, the fetal CP express many enzymes for phase I-III metabolisms as well as transporters suggesting that it can greatly influence drug disposition and has a significant machinery to deactivate reactive molecules with only minor gestational changes. In summary, the study suggests that from, at least, midgestation, the CP in the nonhuman primate is restrictive and express most known genes associated with barrier function and transport.
Useful keywords (using NLM MeSH Indexing)
Animals
Antioxidants/metabolism
Biotransformation
Blood-Brain Barrier/growth*
development
Blood-Brain Barrier/metabolism*
Choroid Plexus/growth*
development
Choroid Plexus/metabolism*
Female
Gene Expression Regulation, Developmental
Gestational Age
Membrane Transport Proteins/genetics
Membrane Transport Proteins/metabolism*
Models, Animal
Papio hamadryas/genetics
Papio hamadryas/growth*
development
Papio hamadryas/metabolism*
Pregnancy
Tight Junction Proteins/genetics
Tight Junction Proteins/metabolism*
Tight Junctions/metabolism*
Tissue Distribution
Xenobiotics/cerebrospinal fluid
Xenobiotics/metabolism*
Xenobiotics/pharmacokinetics
Find related publications in this database (Keywords)
Choroid plexus