Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

The choroid plexus (CP) is rich in barrier mechanisms including transporters and enzymes which can influence drug disposition between blood and brain. We have limited knowledge of their state in fetus. We have studied barrier mechanisms along with metabolism and transporters influencing xenobiotics, using RNAseq and protein analysis, in the CP during the second-half of gestation in a nonhuman primate (Papio hamadryas). There were no differences in the expression of the tight-junctions at the CP suggesting a well-formed fetal blood-CSF barrier during this period of gestation. Further, the fetal CP express many enzymes for phase I-III metabolisms as well as transporters suggesting that it can greatly influence drug disposition and has a significant machinery to deactivate reactive molecules with only minor gestational changes. In summary, the study suggests that from, at least, midgestation, the CP in the nonhuman primate is restrictive and express most known genes associated with barrier function and transport.

Useful keywords (using NLM MeSH Indexing)

Animals

Antioxidants/metabolism

Biotransformation

Blood-Brain Barrier/growth*

development

Blood-Brain Barrier/metabolism*

Choroid Plexus/growth*

development

Choroid Plexus/metabolism*

Female

Gene Expression Regulation, Developmental

Gestational Age

Membrane Transport Proteins/genetics

Membrane Transport Proteins/metabolism*

Models, Animal

Papio hamadryas/genetics

Papio hamadryas/growth*

development

Papio hamadryas/metabolism*

Pregnancy

Tight Junction Proteins/genetics

Tight Junction Proteins/metabolism*

Tight Junctions/metabolism*

Tissue Distribution

Xenobiotics/cerebrospinal fluid

Xenobiotics/metabolism*

Xenobiotics/pharmacokinetics

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