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Forschungsdatenbank PMU-SQQUID

Current therapies in ischemic stroke. Part B. Future candidates in stroke therapy and experimental studies.
Broussalis, E; Trinka, E; Killer, M; Harrer, A; McCoy, M; Kraus, J;
Drug Discov Today. 2012; 17(13-14):671-684
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PMU-Autor/inn/en

Broussalis Erasmia
Harrer Andrea
Killer-Oberpfalzer Monika
Kraus Jörg
McCoy Mark R.
Trinka Eugen

Abstract

Stroke still remains a major healthcare problem. The growing understanding of the mechanism of cell death in ischemia leads to new approaches in stroke treatment. The aim of neuroprotection is to reduce the post-stroke impairment and the overall costs that are accompanied in patients with severe disability. Despite encouraging data from experimental animal models, almost all neuroprotective therapies have, to date, not been established in clinical routine. In this part B of our review on stroke therapies we provide an overview on future candidates in stroke therapy and neuroprotective agents that are under investigation.


Useful keywords (using NLM MeSH Indexing)

Animals

Brain Ischemia/complications

Brain Ischemia/drug therapy*

Clinical Trials as Topic

Drug Evaluation, Preclinical

Drug Therapy, Combination

Drugs, Investigational/administration*

dosage

Drugs, Investigational/adverse effects

Drugs, Investigational/therapeutic use*

Humans

Intracranial Thrombosis/prevention*

control

Neuroprotective Agents/administration*

dosage

Neuroprotective Agents/adverse effects

Neuroprotective Agents/therapeutic use*

Stroke/drug therapy*

Stroke/etiology

Treatment Outcome