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Forschungsdatenbank PMU-SQQUID

Current therapies in ischemic stroke. Part B. Future candidates in stroke therapy and experimental studies.
Broussalis, E; Trinka, E; Killer, M; Harrer, A; McCoy, M; Kraus, J;
Drug Discov Today. 2012; 17(13-14):671-684


Harrer Andrea
Killer-Oberpfalzer Monika
Kraus Jörg
McCoy Mark R.
Müller-Thies-Broussalis Erasmia
Trinka Eugen


Stroke still remains a major healthcare problem. The growing understanding of the mechanism of cell death in ischemia leads to new approaches in stroke treatment. The aim of neuroprotection is to reduce the post-stroke impairment and the overall costs that are accompanied in patients with severe disability. Despite encouraging data from experimental animal models, almost all neuroprotective therapies have, to date, not been established in clinical routine. In this part B of our review on stroke therapies we provide an overview on future candidates in stroke therapy and neuroprotective agents that are under investigation.

Useful keywords (using NLM MeSH Indexing)


Brain Ischemia/complications

Brain Ischemia/drug therapy*

Clinical Trials as Topic

Drug Evaluation, Preclinical

Drug Therapy, Combination

Drugs, Investigational/administration*


Drugs, Investigational/adverse effects

Drugs, Investigational/therapeutic use*


Intracranial Thrombosis/prevention*


Neuroprotective Agents/administration*


Neuroprotective Agents/adverse effects

Neuroprotective Agents/therapeutic use*

Stroke/drug therapy*


Treatment Outcome