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Forschungsdatenbank PMU-SQQUID

A High Burden of Ischemic Stroke in Regions of Eastern/Central Europe is Largely Due to Modifiable Risk Factors.
Pikija, S; Trkulja, V; Malojcic, B; Mutzenbach, JS; Sellner, J;
Curr Neurovasc Res. 2015; 12(4):341-352
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Mutzenbach Sebastian
Pikija Slaven
Sellner Johann

Abstract

50%) unrecognized before the index event. In a multivariate analysis, odds of stroke increased with tobacco smoking (OR=3.95, 95%CI 1.33-10.8), unhealthy diet (OR=2.12, 1.12-4.01) and AF (OR=9.40, 4.01-22.0), and decreased with higher education (OR=0.33, 0.11-0.98), moderate alcohol consumption (OR=0.48, 0.25-0.93), higher fasting HDL (OR=0.14, 0.07-0.30) and pre-stroke use of anticoagulants (OR=0.09, 0.01-0.59), antihypertensive drugs (OR=0.52, 0.27-1.00) and statins (OR=0.29, 0.12-0.69). Fourteen-day case fatality was 10.8% (S1) and 6.1% (S2) and the risk was higher with AF, cardioembolic stroke, older age, higher fasting serum glucose, and lower with acute aspirin. Among the acute phase survivors, 30.9% died over the subsequent 1-3 years (p<0.05). We conclude that the incidence of ischemic stroke in Croatia is related to conventional risk factors and largely due to a high rate of unawareness and inadequate treatment of predisposing morbidity.


Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Aged, 80 and over

Anti-Arrhythmia Agents/therapeutic use

Atrial Fibrillation/epidemiology

Brain Ischemia/complications*

Brain Ischemia/epidemiology

Case-Control Studies

Cohort Studies

Europe/epidemiology

Female

Humans

Incidence

Male

Middle Aged

Risk Factors

Smoking/epidemiology

Stroke/drug therapy

Stroke/epidemiology*

Stroke/etiology*

Stroke/mortality

Young Adult


Find related publications in this database (Keywords)

Ischemic stroke
Incidence
Mortality
Primary prevention
Secondary prevention