Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

We used transcranial magnetic stimulation (TMS) to explore if an impairment of central sensory function produced by an isolated lesion in the cervical posterior white columns would change motor cortex excitability. Cortical silent period duration was prolonged when compared with the control subjects, while central motor conduction and motor thresholds were in the normal limits. We first demonstrate that the involvement of the ascending proprioceptive sensory pathways in spinal cord diseases may have direct consequences on the activity of intracortical inhibitory interneuronal circuits. These findings further elucidate the role of afferent inputs in motor cortex reorganisation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Useful keywords (using NLM MeSH Indexing)

Adult

Afferent Pathways/injuries*

Afferent Pathways/pathology

Afferent Pathways/physiopathology*

Evoked Potentials, Motor/physiology

Humans

Magnetic Resonance Imaging

Male

Mechanoreceptors/physiology

Motor Cortex/physiopathology*

Muscle Spindles/physiology

Myelitis, Transverse/diagnosis

Neural Inhibition/physiology

Neural Pathways/physiopathology

Proprioception/physiology*

Somatosensory Disorders/pathology

Somatosensory Disorders/physiopathology*

Spinal Cord Injuries/pathology

Spinal Cord Injuries/physiopathology*

Transcranial Magnetic Stimulation

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