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Motor cortex excitability changes following a lesion in the posterior columns of the cervical spinal cord.
Nardone, R; Golaszewski, S; Bergmann, J; Venturi, A; Prünster, I; Bratti, A; Ladurner, G; Tezzon, F;
NEUROSCI LETT. 2008; 434(1): 119-123.


Bergmann Jürgen
Golaszewski Stefan
Nardone Raffaele


We used transcranial magnetic stimulation (TMS) to explore if an impairment of central sensory function produced by an isolated lesion in the cervical posterior white columns would change motor cortex excitability. Cortical silent period duration was prolonged when compared with the control subjects, while central motor conduction and motor thresholds were in the normal limits. We first demonstrate that the involvement of the ascending proprioceptive sensory pathways in spinal cord diseases may have direct consequences on the activity of intracortical inhibitory interneuronal circuits. These findings further elucidate the role of afferent inputs in motor cortex reorganisation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Useful keywords (using NLM MeSH Indexing)


Afferent Pathways/injuries*

Afferent Pathways/pathology

Afferent Pathways/physiopathology*

Evoked Potentials, Motor/physiology


Magnetic Resonance Imaging



Motor Cortex/physiopathology*

Muscle Spindles/physiology

Myelitis, Transverse/diagnosis

Neural Inhibition/physiology

Neural Pathways/physiopathology


Somatosensory Disorders/pathology

Somatosensory Disorders/physiopathology*

Spinal Cord Injuries/pathology

Spinal Cord Injuries/physiopathology*

Transcranial Magnetic Stimulation

Find related publications in this database (Keywords)

transcranial magnetic stimulation
cortical silent period
posterior columns
somatosensory afferents