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Forschungsdatenbank PMU-SQQUID

Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study.
Nardone, R; Bergmann, J; Tezzon, F; Ladurner, G; Golaszewski, S;
J NEURAL TRANSM. 2008; 115(5): 737-743.
Originalarbeiten (Zeitschrift)


Bergmann Jürgen
Golaszewski Stefan
Nardone Raffaele


Little is known about the neurochemical pathology of vascular dementia (VD); it was suggested that cholinergic mechanisms play a role in the pathogenesis of VD, as well as been established for Alzheimerxxxs disease (AD). A recently devised test of motor cortex excitability, the short latency afferent inhibition (SAI), has been proven to depend upon the activity of cholinergic circuits in the human brain. To evaluate, in vivo, the functional role of the cholinergic system in the cognitive dysfunction associated with VD, we used this test in 20 patients with subcortical ischemic VD (SIVD) and in 25 control subjects. Mean SAI was significantly reduced in the SIVD patients; however, individual data varied widely, with SAI responses ranging from normal to markedly reduced values. These findings provide physiological evidence for an important role for cholinergic mechanisms in the pathogenesis of VD. The evaluation of SAI, similar to that described in AD patients, could help in identifying those patients who are more likely to respond to treatment with cholinergic drugs.

Useful keywords (using NLM MeSH Indexing)


Dementia, Vascular/pathology*

Dementia, Vascular/physiopathology*

Electric Stimulation/methods

Evoked Potentials, Motor/physiology*




Middle Aged

Motor Cortex/physiopathology*

Neuropsychological Tests

Reaction Time/physiology

Reaction Time/radiation effects

Statistics, Nonparametric

Transcranial Magnetic Stimulation*

Find related publications in this database (Keywords)

subcortical ischaemic vascular dementia
Alzheimerxxxs disease
transcranial magnetic stimulation
afferent inhibition