Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

OBJECTIVE
The purpose of this work is to evaluate two signal-inducing bone cements for MRI-guided spinal cementoplasty.
The bone cements were made of polymethylmethacrylate (PMMA, 5 ml monomeric, 12 g polymeric) and gadoterate meglumine as a contrast agent (CA, 0-40 μl) with either saline solution (NaCl, 2-4 ml) or hydroxyapatite bone substitute (HA, 2-4 ml). The cement"s signal was assessed in an open 1-Tesla MR scanner, with T1W TSE and fast interventional T1W TSE pulse sequences, and the ideal amount of each component was determined. The compressive and bending strength for different amounts of NaCl and HA were evaluated.
The cement"s MRI signal depended on the concentration of CA, the amount of NaCl or HA, and the pulse sequence. The signal peaks were recorded between 1 and 10 μl CA per ml NaCl or HA, and were higher in fast T1W TSE than in T1W TSE images. The NaCl-PMMA-CA cements had a greater MRI signal intensity and compressive strength; the HA-PMMA-CA cements had a superior bending strength.
Concerning the MR signal and biomechanical properties, these cements would permit MRI-guided cementoplasty. Due to its higher signal and greater compressive strength, the NaCl-PMMA-CA compound appears to be superior to the HA-PMMA-CA compound.

Useful keywords (using NLM MeSH Indexing)

Bone Cements/diagnostic use

Bone Cements/therapeutic use

Contrast Media/administration*

dosage

Humans

Magnetic Resonance Imaging/methods*

Magnetic Resonance Imaging, Interventional/instrumentation

Magnetic Resonance Imaging, Interventional/methods*

Materials Testing

Meglumine/administration*

dosage*

Meglumine/diagnostic use*

Organometallic Compounds/administration*

dosage*

Organometallic Compounds/diagnostic use*

Phantoms, Imaging

Polymethyl Methacrylate/administration*

dosage*

Polymethyl Methacrylate/diagnostic use*

Reproducibility of Results

Sensitivity and Specificity

Vertebroplasty/methods*

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