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Forschungsdatenbank PMU-SQQUID

The role of fabric in the quasi-static compressive mechanical properties of human trabecular bone from various anatomical locations.
Matsuura, M; Eckstein, F; Lochmüller, EM; Zysset, PK;
Biomech Model Mechanobiol. 2008; 7(1):27-42
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Eckstein Felix

Abstract


Osteoporosis leads to an increased risk of bone fracture. While bone density and architecture can be assessed in vivo with increasing accuracy using CT and MRI, their relationship with the critical mechanical properties at various anatomical sites remain unclear. The objective of this study was to quantify the quasi-static compressive mechanical properties of human trabecular bone among different skeletal sites and compare their relationships with bone volume fraction and a measure of microstructural anisotropy called fabric. Over 600 trabecular bone samples from six skeletal sites were assessed by microCT and tested in uniaxial compression. Bone volume fraction correlated positively with elastic modulus, yield stress, ultimate stress, and the relationships depended strongly on skeletal site. The account of fabric improved these correlations substantially, especially when the data of all sites were pooled together, but the fabric-mechanical property relationships remained somewhat distinct among the anatomical sites. The study confirms that, beyond volume fraction, fabric plays an important role in determining the mechanical properties of trabecular bone and should be exploited in mechanical analysis of clinically relevant sites of the human skeleton.


Useful keywords (using NLM MeSH Indexing)

Bone and Bones/anatomy*

histology

Bone and Bones/physiology*

Humans

Materials Testing*

Tomography, X-Ray Computed


Find related publications in this database (Keywords)

compression
fabric
quasi-static
mechanical testing
stiffness
trabecular bone
volume fraction
yield