PMU-Autor/inn/en
Wagner ManfredAbstract
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
Useful keywords (using NLM MeSH Indexing)
Algorithms
Cluster Analysis
Colony Count, Microbial
Cytokines/genetics
Cytokines/metabolism
Gene Expression Profiling*
Gene Expression Regulation*
Genes, Immunoglobulin
Humans
Immunity, Cellular
Immunity, Innate
Leprosy, Lepromatous/classification*
Leprosy, Lepromatous/genetics*
Leprosy, Lepromatous/immunology
Leprosy, Lepromatous/physiopathology
Leprosy, Tuberculoid/classification*
Leprosy, Tuberculoid/genetics*
Leprosy, Tuberculoid/immunology
Leprosy, Tuberculoid/physiopathology
Macrophages, Alveolar/microbiology
Membrane Glycoproteins/immunology
Mycobacterium tuberculosis/growth*
development
Mycobacterium tuberculosis/immunology
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Principal Component Analysis
Receptors, Cell Surface/immunology
Receptors, Immunologic/genetics
Receptors, Immunologic/metabolism
Toll-Like Receptors
Up-Regulation