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Forschungsdatenbank PMU-SQQUID

The ICln interactome.
Fürst, J; Bottà, G; Saino, S; Dopinto, S; Gandini, R; Dossena, S; Vezzoli, V; Rodighiero, S; Bazzini, C; Garavaglia, ML; Meyer, G; Jakab, M; Ritter, M; Wappl-Kornherr, E; Paulmichl, M;
Acta Physiol (Oxf). 2006; 187(1-2):43-49
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PMU-Autor/inn/en

Dossena Silvia
Jakab Martin
Paulmichl Markus
Ritter Markus

Abstract

The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one-protein-one-function base. Therefore, the study of the interactome of the different proteins is of utmost importance. Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a "connector hub" with "date hub" function.


Useful keywords (using NLM MeSH Indexing)

Binding Sites

Cell Membrane/metabolism

Cells/metabolism*

Humans

Ion Channel Gating*

Ion Channels/metabolism*

Proteomics

Signal Transduction/physiology*

Structure-Activity Relationship


Find related publications in this database (Keywords)

ICln
interactomics
ion channels
methylosome
proteomics
RNA-processing
volume regulation