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Forschungsdatenbank PMU-SQQUID

Elevated levels of interleukin 17A and kynurenine in candidemic patients, compared with levels in noncandidemic patients in the intensive care unit and those in healthy controls.
Krause, R; Zollner-Schwetz, I; Salzer, HJ; Valentin, T; Rabensteiner, J; Prüller, F; Raggam, R; Meinitzer, A; Prattes, J; Rinner, B; Strohmaier, H; Quehenberger, F; Strunk, D; Heidrich, K; Buzina, W; Hoenigl, M;
J Infect Dis. 2015; 211(3):445-451
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract

The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine, and T cells has been studied in murine and ex vivo human studies, but data are lacking from patients with invasive fungal infections. Interleukin 17A (IL-17A) is considered an important component in host defense against Candida infections and is modulated by Candida-induced impairment of tryptophan-kynurenine metabolism.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Aged

Aged, 80 and over

Candida

Candidiasis/metabolism*

Candidiasis/microbiology

Case-Control Studies

Female

Humans

Intensive Care Units

Interferon-gamma/metabolism

Interleukin-17/metabolism*

Kynurenine/metabolism*

Lectins, C-Type/metabolism

Male

Middle Aged

Prospective Studies

T-Lymphocytes, Regulatory/metabolism

Toll-Like Receptor 2/metabolism

Toll-Like Receptor 4/metabolism

Tryptophan/metabolism

Young Adult


Find related publications in this database (Keywords)

candida
interleukins
kynurenine