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Forschungsdatenbank PMU-SQQUID

Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review.
Nardone, R; Höller, Y; Brigo, F; Orioli, A; Tezzon, F; Schwenker, K; Christova, M; Golaszewski, S; Trinka, E;
Brain Res. 2015; 1619:139-154


Golaszewski Stefan
Höller Yvonne
Nardone Raffaele
Schwenker Kerstin
Trinka Eugen


We performed here a systematic review of the studies using transcranial magnetic stimulation (TMS) as a research and clinical tool in patients with spinal cord injury (SCI). Motor evoked potentials (MEPs) elicited by TMS represent a highly accurate diagnostic test that can supplement clinical examination and neuroimaging findings in the assessment of SCI functional level. MEPs allows to monitor the changes in motor function and evaluate the effects of the different therapeutic approaches. Moreover, TMS represents a useful non-invasive approach for studying cortical physiology, and may be helpful in elucidating the pathophysiological mechanisms of brain reorganization after SCI. Measures of motor cortex reactivity, e.g., the short interval intracortical inhibition and the cortical silent period, seem to point to an increased cortical excitability. However, the results of TMS studies are sometimes contradictory or divergent, and should be replicated in a larger sample of subjects. Understanding the functional changes at brain level and defining their effects on clinical outcome is of crucial importance for development of evidence-based rehabilitation therapy. TMS techniques may help in identifying neurophysiological biomarkers that can reliably assess the extent of neural damage, elucidate the mechanisms of neural repair, predict clinical outcome, and identify therapeutic targets. Some researchers have begun to therapeutically use repetitive TMS (rTMS) in patients with SCI. Initial studies revealed that rTMS can induce acute and short duration beneficial effects especially on spasticity and neuropathic pain, but the evidence is to date still very preliminary and well-designed clinical trials are warranted. This article is part of a Special Issue entitled SI: Spinal cord injury.

Useful keywords (using NLM MeSH Indexing)


Evoked Potentials, Motor


Motor Activity

Motor Cortex/physiopathology*

Muscle Spasticity/complications

Muscle Spasticity/therapy

Muscle, Skeletal/innervation

Muscle, Skeletal/physiopathology



Psychomotor Disorders/complications

Psychomotor Disorders/therapy

Pyramidal Tracts/physiopathology*

Recovery of Function

Spinal Cord Injuries/complications

Spinal Cord Injuries/diagnosis*

Spinal Cord Injuries/physiopathology*

Spinal Cord Injuries/therapy

Transcranial Magnetic Stimulation*

Find related publications in this database (Keywords)

Spinal cord injury
Motor evoked potentials
Transcranial magnetic stimulation
Repetitive transcranial magnetic stimulation
Central motor conduction
Intracortical inhibition
Therapeutic applications