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Forschungsdatenbank PMU-SQQUID

Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome.
Pikija, S; Cvetko, D; Hajduk, M; Trkulja, V
CLIN NEUROL NEUROSUR. 2009; 111(7): 568-573.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Pikija Slaven

Abstract

OBJECTIVE
Mean platelet volume (MPV) determined shortly after the onset of acute ischemic stroke represents the pre-stroke values. Data on its relationship to stroke severity/outcome have been conflicting. We related MPV to infarct volume on CT brain scans and risk of death/dependence 7 days and 3 months post-stroke.
MPV (within 30h since stroke onset), infarct volume (13-83h since stroke onset) and clinical outcomes were evaluated in 81 consecutive patients (32 men, age 52-91 years, 10 small artery occlusion, 10 large artery atherosclerosis, 29 cardioembolic, 32 multiple probable/possible etiology).
Higher MPV was independently associated with larger ln-infarct volume [estimate 0.259, 95% confidence interval (CI) 0.004-0.513, P=0.046], greater risk of death/dependence 7 days post-stroke [relative risk (RR)=1.077, 95% CI 1.005-1.115, P=0.036], and greater risk of death/dependence 3 months post-stroke (RR=1.077, 95% CI 1.001-1.158, P=0.048). Considered covariates: stroke etiology, CT scan timing, platelet count and other hematological parameters, demographic variables, history of cerebrovascular, cardiac or cardiovascular diseases, diabetes, serum chemistry, previous antiplatelet and statin use and treatments delivered after the index event.
Data support the view about MPV as a determinant of severity/outcome of the acute ischemic stroke.


Useful keywords (using NLM MeSH Indexing)

Acute Disease

Adult

Aged

Aged, 80 and over

Blood Platelets/physiology*

Brain/radiography*

Brain Ischemia/blood*

Brain Ischemia/complications*

Cerebral Infarction/blood*

Cerebral Infarction/etiology*

Cerebral Infarction/radiography

Female

Humans

Male

Middle Aged

Platelet Count

Predictive Value of Tests

Prognosis

Stroke/blood*

Stroke/etiology*

Tomography, X-Ray Computed

Treatment Outcome


Find related publications in this database (Keywords)

Ischemic stroke
Stroke outcome
Infarct volume
CT brain scan
Platelets
Mean platelet volume