Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

Intracranial atherosclerosis is responsible for a substantial proportion of stroke, and vessel calcifications as seen on native computed tomographic scans could be an estimate of its burden. The presence of vertebrobasilar artery calcifications is associated with risk factors. This study is a retrospective clinical study on 449 consecutive patients with stroke. Native computed tomographic scans were assessed for the presence of calcification in the intracranial segment of vertebrobasilar artery, and the area of each vessel was calculated from 2 perpendicular diameters. A comprehensive assessment of standard risk factors was recorded. A total of 245 (54.6%) patients had visible calcifications in vertebrobasilar artery. Calcifications were positively associated with advanced age (odds ratio, 1.04; 95% confidence interval, 1.02-1.06; P<0.001), larger total vessel area (odds ratio, 1.01; 95% confidence interval, 1.00-1.01; P<0.001), and history of previous transient ischemic attack/stroke (odds ratio, 1.82; 95% confidence interval, 1.08-3.07; P=0.024). Higher prevalence of calcifications in vertebrobasilar artery territory of patients with stroke is associated with advanced age, larger arterial area, and history of previous transient ischemic attack/stroke. BACKGROUND AND PURPOSE
Intracranial atherosclerosis is responsible for a substantial proportion of stroke, and vessel calcifications as seen on native computed tomographic scans could be an estimate of its burden. The presence of vertebrobasilar artery calcifications is associated with risk factors.
This study is a retrospective clinical study on 449 consecutive patients with stroke. Native computed tomographic scans were assessed for the presence of calcification in the intracranial segment of vertebrobasilar artery, and the area of each vessel was calculated from 2 perpendicular diameters. A comprehensive assessment of standard risk factors was recorded.
A total of 245 (54.6%) patients had visible calcifications in vertebrobasilar artery. Calcifications were positively associated with advanced age (odds ratio, 1.04; 95% confidence interval, 1.02-1.06; P<0.001), larger total vessel area (odds ratio, 1.01; 95% confidence interval, 1.00-1.01; P<0.001), and history of previous transient ischemic attack/stroke (odds ratio, 1.82; 95% confidence interval, 1.08-3.07; P=0.024).
Higher prevalence of calcifications in vertebrobasilar artery territory of patients with stroke is associated with advanced age, larger arterial area, and history of previous transient ischemic attack/stroke.

Useful keywords (using NLM MeSH Indexing)

Age Factors

Aged

Aged, 80 and over

Atherosclerosis/pathology

Basilar Artery/pathology*

Brain Ischemia/pathology

Calcinosis/pathology*

Calcinosis/prevention*

control

Cerebral Angiography

Female

Humans

Ischemic Attack, Transient/complications

Ischemic Attack, Transient/pathology

Magnetic Resonance Angiography

Male

Middle Aged

Multivariate Analysis

Odds Ratio

Recurrence

Retrospective Studies

Risk Factors

Vertebral Artery/pathology*

Vertebrobasilar Insufficiency/radiography

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