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Forschungsdatenbank PMU-SQQUID

Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).
Eckstein, F; Buck, RJ; Wyman, BT; Kotyk, JJ; Le Graverand, MP; Remmers, AE; Evelhoch, JL; Hudelmaier, M; Charles, HC;
MAGN RESON MED. 2007; 58(2): 402-406.
Originalarbeiten (Zeitschrift)


Eckstein Felix
Hudelmaier Martin


MRI-based cartilage morphometry was previously validated in the absence of gadopentate dimeglumine (Gd-DTPA). However, Gd-DTPA is required for compositional (proteoglycan) imaging using delayed gadolinium-enhanced MRI of cartilage (dGEM-RIC). Therefore, the effect of Gd-DTPA on cartilage morphometry was studied. A total of 165 female participants (67 with and 98 without osteoarthritis [OA]) were imaged at 3.0 Tesla before and 2 hr after intravenous Gd-DTPA injection. Flip angles in post-Gd-DTPA scans varied between 12 degrees and 35 degrees. Cartilage volume and thickness of post- vs. pre-Gd-DTPA scans showed intraclass correlation coefficients (ICCs) of 0.85 >= r >= 0.95, mean differences between -2.1% and +1.1%, and standard deviations (SDs) of differences between 4.7% and 9.2%. Mixed-effect models found no consistent impact of flip angle and OA status on post- vs. pre-Gd-DTPA differences. Accurate morphological measurements of cartilage can be obtained after Gd-DTPA injection, allowing compositional and morphological imaging to be combined into one session.

Useful keywords (using NLM MeSH Indexing)



Cartilage, Articular/pathology*

Contrast Media

Cross-Sectional Studies


Gadolinium DTPA/administration*



Image Processing, Computer-Assisted

Injections, Intravenous

Magnetic Resonance Imaging/methods*

Middle Aged

Osteoarthritis, Knee/pathology*

Reproducibility of Results

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