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Forschungsdatenbank PMU-SQQUID

Radiological evaluation of cartilage after microfracture treatment: a long-term follow-up study.
Von Keudell, A; Atzwanger, J; Forstner, R; Resch, H; Hoffelner, T; Mayer, M;
Eur J Radiol. 2012; 81(7):1618-1624
Originalarbeiten (Zeitschrift)


Forstner Rosemarie
Hoffelner Thomas
Mayer Michael
Resch Herbert


Introduction: Recent literature revealed good short-term results after microfracturing (MFX) of isolated focal cartilage defects in the knee joint. Study purpose was a long-term evaluation of patients who received MFX through a multimodal approach, correlating clinical scores and morphological pre- and postoperative MRI-scans. Materials and methods: Between 2000 and 2007 158 patients were treated with MFX for focal femoral or tibial defects at our department. Patients with instabilities, secondary surgical intervention, patellofemoral lesions, a plica mediopatellaris or more than one cartilage defect site and age >55 were excluded. 15 patients were included. Minimum postoperative follow-up (FU) was 18 months (18-78 m). Mean age at surgery was 45 years (27-54), mean FU-interval 48 months (18-78 m). Male to female ratio was 9:6. For clinical assessment the Knee Osteoarthritis Outcome Score (KOOS) and Lysholm Score were used, radiological evaluation was performed with radiographs and 3Tesla-MRI. Results: Clinical knee function was rated good to excellent in 1 patient, fair in 2 and poor in 10 patients. 2/15 patients received full knee replacement due to insufficient cartilage repair through MFX during FU period. Evaluation of pre- and postoperative MRI showed good cartilage repair tissue in 1 (7.7%), moderate repair in 2 (15.4%) and poor fill in 10 patients (76.9%). In these 10 patients the defect size increased. Average defect size preoperatively was 187 mm(2) (range 12-800 mm(2)) and postoperatively 294 mm(2) (40-800 mm(2)). The KOOS-Pain averaged 60 (39-94), KOOS-Symptoms 60.6 (21-100), KOOS-ADL 69 (21-91), KOOS-Sports 35.7 (5-60) and KOOS-QUL 37.2 (6-81). The average Lysholm Score was 73.9 (58-94). 10 patients showed a varus leg axis deviation (empty set 5.9 degrees), 3 had a neutral alignment. The alignment correlated positively with KOOS and especially with the Lysholm Score. Conclusion: Our study demonstrated that MFX as a treatment option for cartilage defect in the knee did not show the anticipated clinical and radiological long-term results. In 12 of 15 patients the cartilage defect size had increased after MFX, in 2 patients indicating full-knee replacement. Especially those with a leg malalignment >5 degrees in varus were more prone to suffer from an increase in defect size. In our cohort the clinical scores correlated with the radiological findings. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Useful keywords (using NLM MeSH Indexing)


Arthroplasty, Subchondral*

Cartilage, Articular/pathology*

Cartilage, Articular/ultrastructure*


Follow-Up Studies


Knee Injuries/pathology

Knee Injuries/surgery*

Longitudinal Studies

Magnetic Resonance Imaging/methods*


Middle Aged

Retrospective Studies

Statistics, Nonparametric

Treatment Outcome

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