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Forschungsdatenbank PMU-SQQUID

Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.
Kinzer, M; Hingerl, K; Konig, J; Reinisch, A; Strunk, D; Huppertz, B; Lang, I
PLACENTA. 2014; 35(7): 517-519.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract


Cell transplantation is a promising strategy in regenerative medicine for revascularization of ischemic tissues. Based on our observation that placental mesenchymal stromal cells (PMSC) enhance endothelial cell viability in vitro via secretion of angiogenic factors, we asked whether PMSC support vascular growth in vivo. PMSC were isolated from amnion and placental endothelial cells (PLEC) from chorion and either separately or co-transplanted subcutaneously into immune-deficient mice. Co-transplantation resulted in a higher number of perfused human vessels (CD31+/vimentin+) containing mouse glycophorin A+ erythrocytes. Results indicate positive effects of PMSC on neovascularization in vivo, making them attractive candidates to create autologous PMSC/PLEC pairs for research and transplantation.


Find related publications in this database (Keywords)

Human placenta
Mesenchymal stromal cells
Vascularization
Angiogenesis
Mouse model