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Forschungsdatenbank PMU-SQQUID

Protein S-100B--a prognostic marker for cerebral damage.
Stroick, M; Fatar, M; Ragoschke-Schumm, A; Fassbender, K; Bertsch, T; Hennerici, MG
Curr Med Chem. 2006; 13(25):3053-3060
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PMU-Autor/inn/en

Bertsch Thomas

Abstract

The assessment of S-100B in acute neurological disorders such as global hypoxia, ischaemic or haemorrhagic stroke and traumatic brain injury reflects severity of symptoms and outcome. However, the temporal profile of S-100B release depends on topography, intensity and pathophysiology of the damage e.g. immediate release after traumatic brain injury following the acute destruction of neuronal tissue or delayed release after ischaemic stroke in which gradual breakdown of the blood-brain barrier plays a crucial role. In chronic brain diseases, knowledge about the clinical value of quantification of S-100B is scarce and further evaluations are needed. This review considers both conditions for S-100B measurement and illustrates advantages and limitations in comparison with clinical and neuroimaging data.


Useful keywords (using NLM MeSH Indexing)

Animals

Biomarkers/blood*

Blood-Brain Barrier/metabolism

Blood-Brain Barrier/pathology

Brain Injuries/blood

Brain Injuries/diagnosis*

Brain Ischemia/blood

Brain Ischemia/diagnosis

Cell Hypoxia/physiology

Cerebral Hemorrhage/blood

Cerebral Hemorrhage/diagnosis

Cerebrovascular Disorders/blood

Cerebrovascular Disorders/diagnosis*

Humans

Prognosis

S100 Proteins/blood*

Trauma Severity Indices


Find related publications in this database (Keywords)

S-100B
stroke
global hypoxia
traumatic brain injury