' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

Glucocorticoid treatment of ovariectomized sheep affects mineral density, structure, and mechanical properties of cancellous bone.
Schorlemmer, S; Gohl, C; Iwabu, S; Ignatius, A; Claes, L; Augat, P;
J BONE MINER RES. 2003; 18(11): 2010-2015.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Augat Peter

Abstract

Thus far, orthopedic research lacks a suitable animal model of osteoporosis. In OVX sheep, 6 months of steroid exposure reduced bone density and mechanical competence. Bone properties and bone formation did not recover for another 6 months. Therefore, steroid-treated OVX sheep may serve as a large animal model for osteopenic bone.


Useful keywords (using NLM MeSH Indexing)

Animals

Bone Density/drug effects*

Bone Density/physiology

Bone and Bones/anatomy*

histology*

Bone and Bones/drug effects*

Bone and Bones/physiology

Female

Femur/anatomy*

histology

Femur/drug effects

Femur/physiology

Glucocorticoids/pharmacology*

Glucocorticoids/therapeutic use

Models, Animal

Osteoporosis/drug therapy

Ovariectomy

Sheep

Spine/anatomy*

histology

Spine/drug effects

Spine/physiology

Tibia/anatomy*

histology

Tibia/drug effects

Tibia/physiology


Find related publications in this database (Keywords)

osteoporosis
corticosteroids
biomechanics
bone histomorphometry
bone quantitative computed tomography