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Abstract

PURPOSE
Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies. We provide an update on hepatotoxic side effects in Germany between 1994 and 2003.
We mailed a questionnaire to all members of the German Section of the International League Against Epilepsy, asking for VPA-induced side effects, especially severe side effects such as hepatopathy.
As a result of our questionnaire, we found 31 cases of reversible hepatotoxicity and nine cases of lethal hepatopathies in Germany from 1994 to 2003.
The outcome of patients with severe hepatotoxicity is better than that in the past. The risk of a VPA-induced hepatopathy is not limited to patients younger than 2 years, receiving polytherapy, or patients with congenital or acquired metabolic diseases.

Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Age Factors

Anticonvulsants/adverse effects*

Anticonvulsants/therapeutic use

Child

Child, Preschool

Comorbidity

Drug Therapy, Combination

Drug-Induced Liver Injury*/epidemiology

Drug-Induced Liver Injury*/etiology*

Drug-Induced Liver Injury*/mortality

Epilepsy/drug therapy*

Epilepsy/epidemiology

Fatal Outcome

Female

Germany/epidemiology

Humans

Infant

Liver Diseases/epidemiology

Liver Diseases/mortality

Liver Failure/chemically induced

Liver Failure/epidemiology

Liver Failure/mortality

Male

Metabolic Diseases/epidemiology

Outcome Assessment (Health Care)

Questionnaires

Risk Factors

Valproic Acid/adverse effects*

Valproic Acid/therapeutic use

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