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Forschungsdatenbank PMU-SQQUID

Comparison of three clinical rating scales in Friedreich ataxia (FRDA).
Bürk, K; Mälzig, U; Wolf, S; Heck, S; Dimitriadis, K; Schmitz-Hübsch, T; Hering, S; Lindig, TM; Haug, V; Timmann, D; Degen, I; Kruse, B; Dörr, JM; Ratzka, S; Ivo, A; Schöls, L; Boesch, S; Klockgether, T; Klopstock, T; Schulz, JB;
Mov Disord. 2009; 24(12):1779-1784
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Hering Sascha

Abstract


To test the validity and reliability of the scale for the assessment and rating of ataxia (SARA) in Friedreich ataxia (FRDA). SARA is limited to eight items and can be performed rapidly. Ninety-six patients with a molecular genetic diagnosis of FRDA were rated using three different clinical scales, the FRDA Rating Scale (FARS), the International Cooperative Ataxia Rating Scale (ICARS), and SARA. Despite considerable discrepancies in scale size and subscale structure, SARA total scores were significantly correlated with ICARS (r = 0.953, P < 0.0001) and FARS (r = 0.938, P < 0.0001) total scores. SARA total scores also correlated with the activities of daily living (ADL, r = 0.929, P < 0.0001). Although originally developed for the use in dominantly inherited ataxias, which are primarily ataxias of the cerebellar type, SARA can also be used successfully to assess afferent ataxia, which is the predominant form in FRDA. Because SARA is characterized by high interrater reliability and practicability, SARA is applicable and well suited forclinical trials of FRDA.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Aged

Child

Disability Evaluation*

Female

Friedreich Ataxia/diagnosis*

Friedreich Ataxia/genetics

Friedreich Ataxia/physiopathology

Humans

Male

Middle Aged

Outcome Assessment (Health Care)*

Principal Component Analysis

Psychometrics

Reproducibility of Results

Severity of Illness Index*

Statistics as Topic

Young Adult


Find related publications in this database (Keywords)

Friedreich ataxia
clinical rating scales
validation
SARA
ICARS
FARS