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Forschungsdatenbank PMU-SQQUID

Stimulation of the recruitment of epidermal Langerhans cells by splenopentin.
GRUNER, S; DIEZEL, W; STRUNK, D; ZWIRNER, A; SONNICHSEN, N; ANHALT, GJ
Arch Dermatol Res. 1990; 281(8):526-529
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract

Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.


Useful keywords (using NLM MeSH Indexing)

Animals

Cell Count/drug effects

Cyclophosphamide/antagonists*

inhibitors

Dexamethasone/antagonists*

inhibitors

Female

Langerhans Cells/drug effects*

Mice

Mice, Inbred BALB C

Peptide Fragments/pharmacology*

Thymopoietins/pharmacology*

Thymus Hormones/pharmacology*