We compared the frequency, phenotype and function of blood dendritic cells (DC) and their precursors in patients with untreated B cell chronic lymphocytic leukemia (CLL) and in normal individuals. The numbers of CD11c(+) and CD123(+) blood DC were significantly reduced in CLL patients already at diagnosis and these cells showed diminished antigen uptake and perturbed maturation. The number of monocytes was normal and the number of CD34(+) progenitor cells increased in the CLL patientsxxx blood.
Useful keywords (using NLM MeSH Indexing)
Leukemia, Lymphocytic, Chronic, B-Cell/blood
Leukemia, Lymphocytic, Chronic, B-Cell/genetics
Leukemia, Lymphocytic, Chronic, B-Cell/pathology*
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