' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

Inhibition of histamine release from human granulocytes by ions of the rare earth elements lanthanum and cerium.
GRUNER, S; SEHRT, I; MULLER, GM; ZWIRNER, A; STRUNK, D; SONNICHSEN, N
Agents Actions. 1992; 36(3-4):207-211
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract

The influence of the ATPase inhibitors, lanthanum or cerium, on histamine release in basophils and mast cells was studied. Both compounds inhibited IgE- or A23187-induced histamine release. To exclude a general inhibition of calcium-dependent reactions in the cell, we tested the influence of these compounds on phagocytosis and superoxide production of neutrophil granulocytes. Phagocytosis of Candida albicans was inhibited partially, superoxide generation, measured by the INT test after stimulation with zymosan or aggregated gamma globulin, was not affected. Because of the inhibitory effect of lanthanum or cerium compounds on membrane ATPase and immunological function of epidermal Langerhans cells we propose that these compounds may be used in the treatment of atopic eczema, where both histamine-releasing mast cells and IgE-bearing Langerhans cell play a pathogenetically important role.


Useful keywords (using NLM MeSH Indexing)

Calcimycin/pharmacology

Calcium/physiology

Candida albicans/immunology

Cerium/pharmacology*

Granulocytes/drug effects

Granulocytes/metabolism*

Histamine Release/drug effects*

Humans

In Vitro Techniques

Lanthanum/pharmacology*

Phagocytosis/drug effects

Superoxides/metabolism