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Forschungsdatenbank PMU-SQQUID

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma.
Deutsch, AJA; Steinbauer, E; Hofmann, NA; Strunk, D; Gerlza, T; Beham-Schmid, C; Schaider, H; Neumeister, P
MODERN PATHOL. 2013; 26(2): 182-194.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract

Chemokine receptors have a crucial role in the development and progression of lymphoid neoplasms. To determine the chemokine receptor expression profile in gastric mucosa-associated lymphoid tissue (MALT) lymphoma, we performed an expression analysis of 19 chemokine receptors at mRNA levels by using real-time RT-PCR, as well as of five chemokine receptors-CCR8, CCR9, CXCR4, CXCR6 and CXCR7-by immunohistochemistry on human tissue samples of Helicobacter pylori-associated gastritis, gastric MALT lymphoma and gastric extranodal diffuse large B-cell lymphoma originating from MALT lymphoma (transformed MALT lymphoma). Following malignant transformation from H. pylori-associated gastritis to MALT lymphoma, an upregulation of CCR7, CXCR3 and CXCR7, and a loss of CXCR4 were detected. The transformation of gastric MALT lymphomas to gastric extranodal diffuse large B-cell lymphoma was accompanied by upregulation of CCR1, CCR5, CCR7, CCR8, CCR9, CXCR3, CXCR6, CXCR7 and XCR1. Remarkably, CXCR4 expression was exclusively found in nodal marginal B-cell lymphomas and nodal diffuse large B-cell lymphomas but not at extranodal manifestation sites, le, in gastric MALT lymphomas or gastric extranodal diffuse large B-cell lymphomas. Furthermore, the incidence of bone marrow infiltration (16/51 with bone marrow involvement vs 35/51 with bone marrow involvement; Spearman rho = 0467 P<0.001) positively correlated with CXCR4 expression. CXCL12, the ligand of CXCR4 and CXCR7, was expressed by epithelial, endothelial and inflammatory cells, MALT lymphoma cells and was most strongly expressed by extranodal diffuse large B-cell lymphoma cells, suggesting at least in part an autocrine signaling pathway. Our data indicate that CXCR4 expression is associated with nodal manifestation and a more advanced stage of lymphomas and hence, might serve as useful clinical prognostic marker. Modern Pathology (2013) 26, 182-194; doi:10.1038/modpathol.2012.134; published online 31 August 2012


Useful keywords (using NLM MeSH Indexing)

Disease Progression

Gastritis/genetics

Gastritis/metabolism

Gastritis/pathology

Helicobacter Infections/genetics

Helicobacter Infections/metabolism

Helicobacter Infections/pathology

Helicobacter pylori

Humans

Lymphoma, B-Cell, Marginal Zone/genetics*

Lymphoma, B-Cell, Marginal Zone/metabolism

Lymphoma, B-Cell, Marginal Zone/pathology

Lymphoma, Large B-Cell, Diffuse/genetics*

Lymphoma, Large B-Cell, Diffuse/metabolism

Receptors, CXCR/genetics*

Receptors, CXCR/metabolism

Receptors, CXCR4/genetics*

Receptors, CXCR4/metabolism

Receptors, Chemokine/genetics

Receptors, Chemokine/metabolism

Stomach Neoplasms/genetics*

Stomach Neoplasms/metabolism

Stomach Neoplasms/pathology

Up-Regulation*


Find related publications in this database (Keywords)

chemokines
chemokine receptor
CXCR4
CXCR7
MALT lymphoma
transformed MALT lymphoma