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Forschungsdatenbank PMU-SQQUID

Endothelial colony-forming progenitor cell isolation and expansion.
Hofmann, NA; Reinisch, A; Strunk, D;
Methods Mol Biol. 2012; 879: 381-387.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Strunk Dirk

Abstract


Vessel wall-derived somatic endothelial colony-forming progenitor cells (ECFCs) are key players in vascular homeostasis and regeneration. Due to their robust proliferative potential and profound vessel-forming capacity, ECFCs are considered to represent an attractive tool for vascular regenerative medicine and a promising target for antiangiogenic tumor therapy. Here, we describe an easily applicable method for isolating ECFCs directly from unmanipulated adult human blood and an animal protein-free large-scale expansion system to generate more than 100 million functional ECFCs.


Useful keywords (using NLM MeSH Indexing)

Animals

Cell Proliferation

Cell Separation*

Endothelial Cells/cytology*

Humans

Stem Cells/cytology*