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Forschungsdatenbank PMU-SQQUID

European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG).
Schmoll, HJ; Souchon, R; Krege, S; Albers, P; Beyer, J; Kollmannsberger, C; Fossa, SD; Skakkebaek, NE; de Wit, R; Fizazi, K; Droz, JP; Pizzocaro, G; Daugaard, G; de Mulder, PH; Horwich, A; Oliver, T; Huddart, R; Rosti, G; Paz Ares, L; Pont, O; Hartmann, JT; Aass, N; Algaba, F; Bamberg, M; Bodrogi, I; Bokemeyer, C; Classen, J; Clemm, S; Culine, S; de Wit, M; Derigs, HG; Dieckmann, KP; Flasshove, M; Garcia del Muro, X; Gerl, A; Germa-Lluch, JR; Hartmann, M; Heidenreich, A; Hoeltl, W; Joffe, J; Jones, W; Kaiser, G; Klepp, O; Kliesch, S; Kisbenedek, L; Koehrmann, KU; Kuczyk, M; Laguna, MP; Leiva, O; Loy, V; Mason, MD; Mead, GM; Mueller, RP; Nicolai, N; Oosterhof, GO; Pottek, T; Rick, O; Schmidberger, H; Sedlmayer, F; Siegert, W; Studer, U; Tjulandin, S; von der Maase, H; Walz, P; Weinknecht, S; Weissbach, L; Winter, E; Wittekind, C;
Ann Oncol. 2004; 15(9):1377-1399


Sedlmayer Felix


Germ cell tumour is the most frequent malignant tumour type in young men with a 100% rise in the incidence every 20 years. Despite this, the high sensitivity of germ cell tumours to platinum-based chemotherapy, together with radiation and surgical measures, leads to the high cure rate of greater than or equal to99% in early stages and 90%, 75-80% and 50% in advanced disease with xxxgoodxxx, xxxintermediatexxx and xxxpoorxxx prognostic criteria (IGCCCG classification), respectively. The high cure rate in patients with limited metastatic disease allows the reduction of overall treatment load, and therefore less acute and longterm toxicity, e.g. organ sparing surgery for specific cases, reduced dose and treatment volume of irradiation or substitution of node dissection by surveillance or adjuvant chemotherapy according to the presence or absence of vascular invasion. Thus, different treatment options according to prognostic factors including histology, stage and patient factors and possibilities of the treating centre as well may be used to define the treatment strategy which is definitively chosen for an individual patient. However, this strategy of reduction of treatment load as well as the treatment itself require very high expertise of the treating physician with careful management and follow-up and thorough cooperation by the patient as well to maintain the high rate for cure. Treatment decisions must be based on the available evidence which has been the basis for this consensus guideline delivering a clear proposal for diagnostic and treatment measures in each stage of gonadal and extragonadal germ cell tumour and individual clinical situations. Since this guideline is based on the highest evidence level available today, a deviation from these proposals should be a rare and justified exception.

Useful keywords (using NLM MeSH Indexing)



Magnetic Resonance Imaging


Neoplasm Staging

Neoplasms, Germ Cell and Embryonal/diagnosis*

Neoplasms, Germ Cell and Embryonal/therapy*


Salvage Therapy

Testicular Neoplasms/diagnosis*

Testicular Neoplasms/therapy*


Time Factors

Tomography, X-Ray Computed

Find related publications in this database (Keywords)

consensus on diagnosis and treatment
germ cell tumour
testicular cancer