' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

Hippocampal abnormalities in malformations of cortical development: MRI study.
Kuchukhidze, G; Koppelstaetter, F; Unterberger, I; Dobesberger, J; Walser, G; Zamarian, L; Haberlandt, E; Maier, H; Ortler, M; Gotwald, T; Gelpi, E; Czech, T; Feucht, M; Bauer, G; Delazer, M; Felber, S; Trinka, E;
Neurology. 2010; 74(20): 1575-1582.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Dobesberger Judith
Kuchukhidze Giorgi
Trinka Eugen

Abstract

OBJECTIVES
Hippocampal abnormalities may coexist with malformations of cortical development (MCD). This cross-sectional MRI study aimed at categorizing hippocampal abnormalities in a large group of MCD and comparing MCD patients with (group W) and without (group W/O) hippocampal abnormalities.
Hippocampal anatomy, rotation, size, internal structure, and MRI signal alterations were assessed visually by 3 independent raters in patients with MCD and epilepsy. Four types of hippocampal abnormalities were examined in 220 patients (116 women, mean age 31 +/- 16.6, range 2-76 years): partially infolded/hypoplastic hippocampus (HH), hippocampal sclerosis (HS), malrotated hippocampus (MH), and enlarged hippocampus (EH). The commonest MCD in the cohort were focal cortical dysplasia (27%), polymicrogyria (PMG) (21%), developmental tumors (15%), and periventricular nodular heterotopia (PNH) (14%).
Hippocampal abnormalities were seen in 69/220 (31%) patients: HH in 34/69 (49%); HS in 18/69 (26%); MH in 15/69 (22%); and EH in 2/69 (3%). PNH (21/30 [70%]) and PMG (22/47 [47%]) were most commonly associated with hippocampal abnormalities. Compared to the W/O group, patients in the W group had a higher rate of learning disability (W 41/69 [59%] vs W/O 56/151 [37%]; p = 0.003) and delayed developmental milestones (W 36/69 [52%] vs W/O 53/151 [35%]; p = 0.025); groups did not differ otherwise with regard to clinical presentation. HH was associated with symptomatic generalized epilepsies (11/34 [32%]) and high rate of learning disability (27/34 [79%]), neurologic deficits (25/34 [73%]), and delayed developmental milestones (23/34 [68%]).
About a third of patients with malformations of cortical development had hippocampal abnormalities. Patients with hypoplastic hippocampus had the most severe clinical phenotype.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Aged

Chi-Square Distribution

Child

Child, Preschool

Cross-Sectional Studies

Electroencephalography

Female

Hippocampus/abnormalities*

Hippocampus/pathology*

Humans

Image Processing, Computer-Assisted

Learning Disorders/pathology

Magnetic Resonance Imaging

Male

Malformations of Cortical Development/pathology*

Middle Aged

Neurons/pathology

Neuropsychological Tests

Organ Size