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Forschungsdatenbank PMU-SQQUID

Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside.
Pistoia, W; van Rietbergen, B; Lochmüller, EM; Lill, CA; Eckstein, F; Rüegsegger, P;
J CLIN DENSITOM. 2004; 7(2): 153-160.
Originalarbeiten (Zeitschrift)


Eckstein Felix


Although osteoporosis is characterized by quantitative (mass) and qualitative (structural) changes, standard clinical techniques (dual-energy X-ray absorptiometry, DXA) only measure the former. Three-dimensional micro-finite-element (micro-FE) models based on high-resolution images can account for structural aspects as well, and it has recently been shown that an improved prediction of distal radius strength is possible with micro-FE analysis. A clinical application of this technique, however, is limited by its high imaging and computational demands. The objective of this study is to investigate if an improved prediction of bone strength can be obtained as well when only a small part of the radius is used for micro-FE modeling. Images of a 1-cm region of the metaphysis of the distal radius of 54 cadaver arms (mean age: 82 +/- 9 SD) made with a three-dimensional peripheral quantitative computed tomography (pQCT) device at 165-mum resolution formed the basis for micro-FE models that were used to predict the bone failure load. Following imaging, specimens were experimentally compressed to failure to produce a Collesxxx-type fracture. Failure loads predicted from micro-FE analyses agreed well with those measured experimentally (R-2 = 0.66, p < 0.001). Lower correlations were observed with bone mass (R-2 = 0.48, p < 0.001) and microstructural parameters (R-2 = 0.47, p < 0.001). Hence, even when only a small region is modeled, micro-FE analysis provides an improved prediction of radius strength.

Useful keywords (using NLM MeSH Indexing)

Absorptiometry, Photon


Aged, 80 and over


Bone Density


Finite Element Analysis*


Imaging, Three-Dimensional


Predictive Value of Tests


Regression Analysis

Find related publications in this database (Keywords)

Collesxxx fracture
dual X-ray absorptiometry (DXA)
finite-element method
peripheral quantitative computer tomography (pQCT)