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Forschungsdatenbank PMU-SQQUID

[Radiologically isolated syndrome: multiple sclerosis based solely on MRI findings?].
Sellner, J; Schirmer, L; Hemmer, B; Mühlau, M;
Nervenarzt. 2010; 81(10): 1208-1217.


Sellner Johann


Incidental brain magnetic resonance imaging (MRI) findings are the result of an increasing usage of MRI in the diagnostic work-up of patients. An adequate assessment of patients in which brain lesions typical for multiple sclerosis (MS) are determined but who have been asymptomatic so far is problematic, especially when Barkhof-Tintoré criteria for spatial dissemination are fulfilled and no other differential diagnosis can be confirmed. This entity, the so-called radiologically isolated syndrome, constitutes a major diagnostic and therapeutic challenge. Two recent studies revealed that a subgroup of patients with radiologically isolated syndrome are at high risk for near-term development of MR-based progression and occurrence of the first clinical event. Hence, the radiologically isolated syndrome has to be classified as a possible preliminary phase of the clinical manifestation of MS in a subgroup of patients and entails in-depth therapeutic considerations. This article covers the current literature for this syndrome and, in the absence of official guidelines, provides a pragmatic diagnostic and therapeutic approach for patient management.

Useful keywords (using NLM MeSH Indexing)





Diagnosis, Differential

Disease Progression



Image Processing, Computer-Assisted/methods*

Incidental Findings*

Magnetic Resonance Imaging/methods*


Middle Aged

Multiple Sclerosis/diagnosis*

Multiple Sclerosis/therapy

Neurologic Examination

Prospective Studies

Risk Factors

Young Adult

Find related publications in this database (Keywords)

Multiple sclerosis
Clinically isolated syndrome
Radiologically isolated syndrome
Magnetic resonance imaging
Diagnostic criteria