Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

Mortality and morbidity rates remain high among patients with herpes simplex virus encephalitis (HSVE). Chemokine-mediated recruitment and activation of leukocytes to focal areas of viral CNS infection are crucial steps in antiviral response and clearance. However, the inflammatory reaction and cellular antiviral response may enhance collateral damage to neurons and account for chronic progressive brain damage. We identified a specific mRNA expression of the interferon-gamma-inducible chemokines (CXCL9, CXCL10 and CXCL11), and RANTES (CCL5) in the acute course and long-term of experimental HSVE. This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE.

Useful keywords (using NLM MeSH Indexing)

Acyclovir/therapeutic use

Animals

Anti-Inflammatory Agents/therapeutic use*

Antiviral Agents/therapeutic use*

Chemokines/genetics

Chemokines/metabolism*

Disease Models, Animal

Drug Interactions

Drug Therapy, Combination

Encephalitis, Herpes Simplex/drug therapy

Encephalitis, Herpes Simplex/metabolism*

Female

Gene Expression Regulation/drug effects*

Methylprednisolone/therapeutic use

Mice

RNA, Messenger/metabolism

Reverse Transcriptase Polymerase Chain Reaction/methods

Time Factors

Viral Load/methods

Find related publications in this database (Keywords)