PMU-Autor/inn/en
Sellner JohannAbstract
Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.
Useful keywords (using NLM MeSH Indexing)
Animals
Brain/metabolism*
Brain/physiopathology
Brain/virology*
Brain Damage, Chronic/physiopathology
Brain Damage, Chronic/prevention*
control
Brain Damage, Chronic/virology
Brain-Derived Neurotrophic Factor/genetics
Cell Survival/genetics
Disease Models, Animal
Encephalitis, Herpes Simplex/genetics*
Encephalitis, Herpes Simplex/metabolism*
Encephalitis, Herpes Simplex/physiopathology
Female
Gene Expression/physiology
Glial Cell Line-Derived Neurotrophic Factor
Mice
Nerve Degeneration/physiopathology
Nerve Degeneration/prevention*
control
Nerve Degeneration/virology
Nerve Growth Factors/genetics*
Neurotrophin 3/genetics
RNA, Messenger/metabolism*
Recovery of Function/genetics
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