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Forschungsdatenbank PMU-SQQUID

Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis.
Sellner, J; Lenhard, T; Haas, J; Einsiedel, Rv; Meyding-Lamadé, U;
Brain Res Mol Brain Res. 2005; 137(1-2):267-271
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Sellner Johann

Abstract

Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.


Useful keywords (using NLM MeSH Indexing)

Animals

Brain/metabolism*

Brain/physiopathology

Brain/virology*

Brain Damage, Chronic/physiopathology

Brain Damage, Chronic/prevention*

control

Brain Damage, Chronic/virology

Brain-Derived Neurotrophic Factor/genetics

Cell Survival/genetics

Disease Models, Animal

Encephalitis, Herpes Simplex/genetics*

Encephalitis, Herpes Simplex/metabolism*

Encephalitis, Herpes Simplex/physiopathology

Female

Gene Expression/physiology

Glial Cell Line-Derived Neurotrophic Factor

Mice

Nerve Degeneration/physiopathology

Nerve Degeneration/prevention*

control

Nerve Degeneration/virology

Nerve Growth Factors/genetics*

Neurotrophin 3/genetics

RNA, Messenger/metabolism*

Recovery of Function/genetics


Find related publications in this database (Keywords)

viral encephalitis
herpes simplex virus
neuroregeneration
brain injury