GIMONA MARIO
Department of Transfusion Medicine
Research Program of Development of Stem Cell-Derived Nanovesicular Therapeutics
Spinal Cord Injury and Tissue Regeneration Center Salzburg
Publications
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Researcher Profile
126 Publications
2023
Journal Articles
Evaluation of the Potential of Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles to Improve Rotator Cuff Healing: A Pilot Ovine Study.
Jenner, F; Wagner, A; Gerner, I; Ludewig, E; Trujanovic, R; Rohde, E; von Rechenberg, B; Gimona, M; Traweger, A
Am J Sports Med. 2023; 51(2):331-342
Full papers/articles (Journal)
2022
Journal Articles
Calorimetry of extracellular vesicles fusion to single phospholipid membrane.
Grava, M; Helmy, S; Gimona, M; Parisse, P; Casalis, L; Brocca, P; Rondelli, V;
Biomol Concepts. 2022; 13(1): 148-155.
Full papers/articles (Journal)
Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations.
Warnecke, A; Staecker, H; Rohde, E; Gimona, M; Giesemann, A; Szczepek, AJ; Di Stadio, A; Hochmair, I; Lenarz, T;
J Clin Med. 2022; 11(24):
Reviews
Conference papers, proceedings, abstracts
A CD73 ENZYME ACTIVITY ASSAY FOR STABILITY AND DOSE-FINDING OF THERAPEUTICALLY-ACTIVE EVS
Arzt, C; Fang, H; Grasmann, E; Kals, C; Bayer, E; Auer, D; Schally, T; Rohde, E; Gimona, M
CYTOTHERAPY. 2022; 24(5): S89-S89.
Abstracts (Journal)
COMPREHENSIVE LABEL-FREE CHARACTERIZATION OF EXTRACELLULAR VESICLES AND THEIR SURFACE PROTEINS
Priglinger, E; Strasser, J; Buchroithner, B; Weber, F; Wolbank, S; Auer, D; Grasmann, E; Arzt, C; Narzt, MS; Grillari, J; Preiner, J; Jacak, J; Gimona, M
TISSUE ENG PT A. 2022; 28: S277-S277.
Abstracts (Journal)
Unpublished conference presentations
Acute intralesional application of extracellular vesicles improves outcomes in a rat model of traumatic spinal cord injury.
Bieler, L; Romanelli, P; Heimel, P; Škokić, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolčić, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojević Radmilović, M; Couillard-Despres, S
FENS Forum 2022
; 09.07. - 13.07.2022; Paris. 2022.
Newspaper/magazine articles
GMP-compliant manufacturing of biologically active cell-derived vesicles produced by extrusion technology
Hui-Chong Lau, Dong Woo Han, Jinhee Park, Edwine Lehner, Carina Kals, Claudia Arzt, Elisabeth Bayer, Daniela Auer, Tanja Schally, Eva Grasmann, Han Fang, Jae-Young Lee, Hyun Soo Lee, Jinah Han, Mario Gimona, Eva Rohde, Shingyu Bae, Seung Wook Oh
Journal of Extracellular Biology. 2022.
Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop
Lucia Paolini, Marta Monguió-Tortajada, Marta Costa, Fabio Antenucci, Mario Barilani, Marta Clos-Sansalvador, André Cronemberger Andrade, Tom A. P. Driedonks, Sara Giancaterino, Stephanie M. Kronstadt, Rachel R. Mizenko, Muhammad Nawaz, Xabier Osteikoetxea, Carla Pereira, Surya Shrivastava, Anders Toftegaard Boysen, Simonides Immanuel van de Wakker, Martijn J. C. van Herwijnen, Xiaoqin Wang, Dionysios C. Watson, Mario Gimona, Maria Kaparakis-Liaskos, Konstantin Konstantinov, Sai Kiang Lim, Nicole Meisner-Kober, Michiel Stork, Peter Nejsum, Annalisa Radeghieri, Eva Rohde, Nicolas Touzet, Marca H. M. Wauben, Kenneth W. Witwer, Antonella Bongiovanni, Paolo Bergese
Journal of Extracellular Biology. 2022.
2021
Journal Articles
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.
Gimona, M; Brizzi, MF; Choo, ABH; Dominici, M; Davidson, SM; Grillari, J; Hermann, DM; Hill, AF; Kleijn, DD; Lai, RC; Lai, CRP; Lim, R; Monguio-Tortajada, M; Muraca, M; Ochiya, T; Ortiz, LA; Toh, WS; Yi, YW; Witwer, KW; Giebel, B; Lim, SK
CYTOTHERAPY. 2021; 23(5): 373-380.
Full papers/articles (Journal)
Structural insights into fusion mechanisms of small extracellular vesicles with model plasma membranes
Perissinotto, F; Rondelli, V; Senigagliesi, B; Brocca, P; Almasy, L; Bottyan, L; Merkel, DG; Amenitsch, H; Sartori, B; Pachler, K; Mayr, M; Gimona, M; Rohde, E; Casalis, L; Parisse, P
NANOSCALE. 2021; 13(10): 5224-5233.
Full papers/articles (Journal)
Label-free characterization of an extracellular vesicle-based therapeutic.
Priglinger, E; Strasser, J; Buchroithner, B; Weber, F; Wolbank, S; Auer, D; Grasmann, E; Arzt, C; Sivun, D; Grillari, J; Jacak, J; Preiner, J; Gimona, M
J EXTRACELL VESICLES. 2021; 10(12): e12156
Full papers/articles (Journal)
Enhancing Functional Recovery Through Intralesional Application of Extracellular Vesicles in a Rat Model of Traumatic Spinal Cord Injury.
Romanelli, P; Bieler, L; Heimel, P; Škokić, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolčić, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojević Radmilović, M; Couillard-Despres, S;
Front Cell Neurosci. 2021; 15: 795008
Full papers/articles (Journal)
Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial.
Uccelli, A; Laroni, A; Ali, R; Battaglia, MA; Blinkenberg, M; Brundin, L; Clanet, M; Fernandez, O; Marriot, J; Muraro, P; Nabavi, SM; Oliveri, RS; Radue, E; Tello, CR; Schiavetti, I; Sellner, J; Sorensen, PS; Sormani, MP; Wuerfel, JT; Freedman, MS
LANCET NEUROL. 2021; 20(11): 917-929.
Full papers/articles (Journal)
First-in-human intracochlear application of human stromal cell-derived extracellular vesicles.
Warnecke, A; Prenzler, N; Harre, J; Kohl, U; Gartner, L; Lenarz, T; Laner-Plamberger, S; Wietzorrek, G; Staecker, H; Lassacher, T; Hollerweger, J; Gimona, M; Rohde, E
J EXTRACELL VESICLES. 2021; 10(8): e12094
Reviews
Unpublished conference presentations
Intralesional administration of extracellular vesicles improves functional recovery in a rat model of traumatic spinal cord injury
Bieler, L; Romanelli, P; Heimel, P; Škokic, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolcic, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojevic Radmilovic, M; Couillard-Despres, S
Austrian Neuroscience Association Meeting; 28.-30.09.2021; Salzburg. 2021.
Extracellular vesicles to improve outcomes after traumatic spinal cord injury
Bieler, L; Romanelli, P; Heimel, P; Škokic, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolcic, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojevic Radmilovic, M; Couillard-Despres, S
Meeting of the Austrian Cluster for Tissue Regeneration; 30.08.-01.09.2021; Vienna. 2021.
Enhancing functional recovery through intralesional application of extracellular vesicles in a rat model of traumatic spinal cord injury
Romanelli, P; Bieler, L; Heimel, P; Skokic, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolcic, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojevic Radmilovic, M; Couillard-Despres, S
Neuroscience 2021; 08.-11.11.2021; Virtual. 2021.
Functional recovery through intralesional application of extracellular vesicles in a rat model of traumatic spinal cord injury
Romanelli, P; Bieler, L; Heimel, P; Skokic, S; Jakubecova, D; Kreutzer, C; Zaunmair, P; Smolcic, T; Benedetti, B; Rohde, E; Gimona, M; Hercher, D; Dobrivojevic Radmilovic, M; Couillard-Despres, S
PMU Virtual Science Get Together 2021; 02.07.2021; Salzburg. 2021.
2020
Journal Articles
International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.
Borger, V; Weiss, DJ; Anderson, JD; Borras, FE; Bussolati, B; Carter, DRF; Dominici, M; Falcon-Perez, JM; Gimona, M; Hill, AF; Hoffman, AM; de Kleijn, D; Levine, BL; Lim, R; Lotvall, J; Mitsialis, SA; Monguio-Tortajada, M; Muraca, M; Nieuwland, R; Nowocin, A; OxxxDriscoll, L; Ortiz, LA; Phinney, DG; Reischl, I; Rohde, E; Sanzenbacher, R; Thery, C; Toh, WS; Witwer, KW; Lim, SK; Giebel, B
CYTOTHERAPY. 2020; 22(9): 482-485.
Full papers/articles (Journal)
Differential fluorescence nanoparticle tracking analysis for enumeration of the extracellular vesicle content in mixed particulate solutions.
Desgeorges, A; Hollerweger, J; Lassacher, T; Rohde, E; Helmbrecht, C; Gimona, M
METHODS. 2020; 177: 67-73.
Full papers/articles (Journal)
SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema.
Priglinger, E; Strohmeier, K; Weigl, M; Lindner, C; Auer, D; Gimona, M; Barsch, M; Jacak, J; Redl, H; Grillari, J; Sandhofer, M; Hackl, M; Wolbank, S
SCI REP-UK. 2020; 10(1): 7211
Full papers/articles (Journal)
Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.
Warnecke, A; Harre, J; Staecker, H; Prenzler, N; Strunk, D; Couillard-Despres, S; Romanelli, P; Hollerweger, J; Lassacher, T; Auer, D; Pachler, K; Wietzorrek, G; Köhl, U; Lenarz, T; Schallmoser, K; Laner-Plamberger, S; Falk, CS; Rohde, E; Gimona, M;
Clin Transl Med. 2020; 10(8): e262
Full papers/articles (Journal)
Book chapters
Multi-technique analysis of extracellular vesicles: not only size matters.
Perissinotto, F; Senigagliesi, B; Vaccari, L; Pachetti, M; D’Amico, F; Amenitsch, H; Sartori, B; Pachler, K; Mayr, M; Gimona, M; Rohde, E; Caponnetto, F; Cesselli, D; Casalis, L; Parisse, P;
In: Antonella Bongiovanni (Ed), Gabriella Pocsfalvi (Ed), Mauro Manno (Ed), Veronika Kralj-Iglič (Ed) editors(s). Advances in Biomembranes and Lipid Self-Assembly.. 32: p. 157-177. (ISBN: 978-0-12-820968-4)
2019
Journal Articles
Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles.
Marolt Presen, D; Traweger, A; Gimona, M; Redl, H;
Front Bioeng Biotechnol. 2019; 7: 352
Reviews
Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing.
Rohde, E; Pachler, K; Gimona, M
CYTOTHERAPY. 2019; 21(6): 581-592.
Reviews
Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury.
Romanelli, P; Bieler, L; Scharler, C; Pachler, K; Kreutzer, C; Zaunmair, P; Jakubecova, D; Mrowetz, H; Benedetti, B; Rivera, FJ; Aigner, L; Rohde, E; Gimona, M; Strunk, D; Couillard-Despres, S;
Front Neurol. 2019; 10: 1225
Full papers/articles (Journal)
Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
Witwer, KW; Van Balkom, BWM; Bruno, S; Choo, A; Dominici, M; Gimona, M; Hill, AF; De Kleijn, D; Koh, M; Lai, RC; Mitsialis, SA; Ortiz, LA; Rohde, E; Asada, T; Toh, WS; Weiss, DJ; Zheng, L; Giebel, B; Lim, SK
J EXTRACELL VESICLES. 2019; 8(1): 1609206
Full papers/articles (Journal)
Conference papers, proceedings, abstracts
Extracellular Vesicles interaction with model membranes
Perissinotto, F; Senigagliesi, B; Rondelli, VM; Sartori, B; Amenitsch, H; Len, A; Gimona, M; Rohde, E; Casalis, L; Parisse, P
EUR BIOPHYS J BIOPHY. 2019; 48: S164-S164.
Abstracts (Journal)
Unpublished conference presentations
Therapeutic potential of the vesicular secretome of human stromal cells
Rohde, E; Hollerweger, J; Lassacher, T; Schallmoser, K; Schulze, J; Warnecke, A; Romanelli, P; Couillard-Despres, S; Traweger, A; Strunk, D; Gimona, M
52. Jahrestagung der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (DGTI); 18.-20.09.2019; Mannheim. 2019.
2017
Journal Articles
Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use.
Gimona, M; Pachler, K; Laner-Plamberger, S; Schallmoser, K; Rohde, E;
Int J Mol Sci. 2017; 18(6):
Full papers/articles (Journal)
An In Vitro Potency Assay for Monitoring the Immunomodulatory Potential of Stromal Cell-Derived Extracellular Vesicles.
Pachler, K; Ketterl, N; Desgeorges, A; Dunai, ZA; Laner-Plamberger, S; Streif, D; Strunk, D; Rohde, E; Gimona, M;
Int J Mol Sci. 2017; 18(7):
Full papers/articles (Journal)
A Good Manufacturing Practice-grade standard protocol for exclusively human mesenchymal stromal cell-derived extracellular vesicles.
Pachler, K; Lener, T; Streif, D; Dunai, ZA; Desgeorges, A; Feichtner, M; Öller, M; Schallmoser, K; Rohde, E; Gimona, M;
Cytotherapy. 2017; 19(4): 458-472.
Full papers/articles (Journal)
Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles
Reiner, AT; Witwer, KW; van Balkom, BWM; de Beer, J; Brodie, C; Corteling, RL; Gabrielsson, S; Gimona, M; Ibrahim, AG; de Kleijn, D; Lai, CP; Lotvall, J; del Portillo, HA; Reischl, IG; Riazifar, M; Salomon, C; Tahara, H; Toh, WS; Wauben, MHM; Yang, VK; Yang, YJ; Yeo, RWY; Yin, H; Giebel, B; Rohde, E; Lim, SK
STEM CELL TRANSL MED. 2017; 6(8):
Reviews
Conference papers, proceedings, abstracts
A potency assay for monitoring the immunomodulatory
potential of stromal cell-derived extracellular vesicles.
Ketterl, N; Pachler, K; Desgeorges, A; Dunai, Z; Laner-Plamberger, S; Streif, D; Strunk, D; Rohde, E; Gimona, M
Human Gene Therapy. 2017; 28: A85-A86.-25th Anniversary Congress of the ESGCT; 17.-20.10.2017; Berlin.
Abstracts (Journal)
Neuroprotective activity of mesenchymal stromal cells and their secreted vesicles in a spinal cord contusion rat model
Romanelli, P; Bieler, L; Scharler, C; Pachler, K; Kreutzer, C; Zaunmair, P; Aigner, L; Rivera, FJ; Rohde, E; Benedetti, B; Gimona, M; Strunk, D; Couillard-Despres, S
TRANSFUS MED HEMOTH. 2017; 44: 76-76.
Abstracts (Journal)
2016
Conference papers, proceedings, abstracts
Efficient expansion of mesenchymal stem/progenitor cells supported by fibrinogen-depleted pooled human platelet lysate
Oller, M; Laner-Plamberger, S; Feichtner, M; Dunai, ZA; Raninger, A; Gimona, M; Hartl, A; Hauser-Kronberger, C; Russe, E; Bieback, K; Rohde, E; Brachtl, G; Scharler, C; Strunk, D; Schallmoser, K
HUM GENE THER. 2016; 27(11): A63-A64.
Abstracts (Journal)
Fibrinogen-Depleted Pooled Human Platelet Lysate for Efficient Expansion of Mesenchymal Stromal Cells
Öller, M; Laner-Plamberger, S; Feichtner, M; Dunai, ZA; Raninger, A; Gimona, M; Hartl, A; Hauser-Kronberger, C; Russe, E; Bieback, K; Rohde, E; Brachtl, G; Scharler, C; Strunk, D; Schallmoser, K
Vox Sanguinis. 2016; 111(Suppl. 1):285--34th International Congress of the ISBT ; 03.-08.09.2016; Dubai.
Abstracts (Journal)
Efficient Expansion of Mesenchymal Stromal Cells by Fibrinogen-Depleted Pooled Human Platelet Lysate
Öller, M; Laner-Plamberger, S; Feichtner, M; Dunai, ZA; Raninger, A; Gimona, M; Hartl, A; Hauser-Kronberger, C; Russe, E; Bieback, K; Rohde, E; Brachtl, G; Scharler, C; Strunk, D; Schallmoser, K
Transfusion Medicine and Hemotherapy. 2016; 43(Suppl.1):71--49. Jahrestagung der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie ; 07.-10.09.2016; Nürnberg.
Abstracts (Journal)
Unpublished conference presentations
RNA Profiling of Naive and Differentiated MSC-Derived EV: Towards miRNA-Based Release Criteria for Future Therapeutic Application of EV in Clinical Trials
Pachler K, Lener T,Streif D, Dunai ZA, Desgeorges A, Kalathur R, Feichtner M, Laner-Plamberger S, Öller M , Schallmoser K, Weidler G, Strunk D, Rohde E, Gimona M
ISEV 2016, Annual Meeting; 04.-07.05.2016; Rotterdam. 2016.
2015
Journal Articles
Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate.
Laner-Plamberger, S; Lener, T; Schmid, D; Streif, DA; Salzer, T; Öller, M; Hauser-Kronberger, C; Fischer, T; Jacobs, VR; Schallmoser, K; Gimona, M; Rohde, E;
J Transl Med. 2015; 13(1): 354
Full papers/articles (Journal)
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.
Lener, T; Gimona, M; Aigner, L; Börger, V; Buzas, E; Camussi, G; Chaput, N; Chatterjee, D; Court, FA; Del Portillo, HA; O"Driscoll, L; Fais, S; Falcon-Perez, JM; Felderhoff-Mueser, U; Fraile, L; Gho, YS; Görgens, A; Gupta, RC; Hendrix, A; Hermann, DM; Hill, AF; Hochberg, F; Horn, PA; de Kleijn, D; Kordelas, L; Kramer, BW; Krämer-Albers, EM; Laner-Plamberger, S; Laitinen, S; Leonardi, T; Lorenowicz, MJ; Lim, SK; Lötvall, J; Maguire, CA; Marcilla, A; Nazarenko, I; Ochiya, T; Patel, T; Pedersen, S; Pocsfalvi, G; Pluchino, S; Quesenberry, P; Reischl, IG; Rivera, FJ; Sanzenbacher, R; Schallmoser, K; Slaper-Cortenbach, I; Strunk, D; Tonn, T; Vader, P; van Balkom, BW; Wauben, M; Andaloussi, SE; Théry, C; Rohde, E; Giebel, B;
J Extracell Vesicles. 2015; 4: 30087
Full papers/articles (Journal)
Biological properties of extracellular vesicles and their physiological functions.
Yáñez-Mó, M; Siljander, PR; Andreu, Z; Zavec, AB; Borràs, FE; Buzas, EI; Buzas, K; Casal, E; Cappello, F; Carvalho, J; Colás, E; Cordeiro-da Silva, A; Fais, S; Falcon-Perez, JM; Ghobrial, IM; Giebel, B; Gimona, M; Graner, M; Gursel, I; Gursel, M; Heegaard, NH; Hendrix, A; Kierulf, P; Kokubun, K; Kosanovic, M; Kralj-Iglic, V; Krämer-Albers, EM; Laitinen, S; Lässer, C; Lener, T; Ligeti, E; Linē, A; Lipps, G; Llorente, A; Lötvall, J; Manček-Keber, M; Marcilla, A; Mittelbrunn, M; Nazarenko, I; Nolte-"t Hoen, EN; Nyman, TA; O"Driscoll, L; Olivan, M; Oliveira, C; Pállinger, É; Del Portillo, HA; Reventós, J; Rigau, M; Rohde, E; Sammar, M; Sánchez-Madrid, F; Santarém, N; Schallmoser, K; Ostenfeld, MS; Stoorvogel, W; Stukelj, R; Van der Grein, SG; Vasconcelos, MH; Wauben, MH; De Wever, O;
J Extracell Vesicles. 2015; 4: 27066
Full papers/articles (Journal)
Conference papers, proceedings, abstracts
Modifications of human platelet lysate for efficient expansion of mesenchymal stromal cells without fibrinogen.
Öller, M: Feichtner, M; Dunai, ZA; Raninger, A; Laner-Plamberger, S; Lener, T; Streif, D; Gimona, M; Hartl, A; Bieback, K; Wiedemann, H; Rohde, E; Strunk, D; Schallmoser, K
Transfus Med Hemother 2015;42(suppl1):p.63. 2015; -48.Jahrestagung der DGTI (Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie e.V.); 15. -18. 09.2015; Basel.
Abstracts (Journal)
Unpublished conference presentations
The accredited academic GMP manufacturing site for mesenchymal stromal cell-derived EVs at the Paracelsus Medical University Salzburg
Gimona, M;
ISEV Research Workshop 2015; 19.-20.10.2015; Singapur. 2015.
Efficient animal serum-free propagation of mesenchymal stem cells by using fibrinogen-depleted modifications of human platelet lysate.
Öller, M; Feichtner, M; Dunai, ZA; Raninger, A; Laner-Plamberger, S; Lener, T; Gimona, M; Hartl, A; Bieback, K; Rohde, E; Strunk, D; Schallmoser, K
World Conference on Regenerative Medicine 2015; 21.-23.10.2015; Leipzig. 2015.
2013
Conference papers, proceedings, abstracts
Human platelet lysate and exosomes improve the in vitro osteogenic pre-differentiation of bone marrow-derived stem cells
Lener, T; Oeller, M; Peckl-Schmid, D; Streif, D; Gimona, M; Rivera, F; Aigner, L; Rohde, E
BONE MARROW TRANSPL. 2013; 48: S78-S78.
Abstracts (Journal)
2012
Conference papers, proceedings, abstracts
Collagen receptor-mediated mechanochemical signalling modulates human pro-angiogenic mesenchymal stem/progenitor cells during neovascularisation
Gimona, M; Rohban, R; Lener, T; Oller, M; Schallmoser, K; Strunk, D; Rohde, E
BONE MARROW TRANSPL. 2012; 47: S317-S317.
Abstracts (Journal)
Collagen Receptor-Mediated Mechanochemical Signaling Contributes to Human Pro-Angiogenic Mesenchymal Stem/Progenitor Cell-Induced Neo-Vasculogenesis
Gimona, M; Rohban, R; Lener, T; Peckl-Schmid, D; Oeller, M; Schallmoser, K; Strunk, D; Rohde, E
BLOOD. 2012; 120(21):
Abstracts (Journal)
Regulation of Mesenchymal Progenitor Cell-Induced Neo-Vascularization by Endothelial Progenitor Cell-Derived Exosomes
Lener, T; Peckl-Schmid, D; Gimona, M; Oeller, M; Rohde, E
BLOOD. 2012; 120(21):
Abstracts (Journal)
2011
Journal Articles
Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells.
Wessler, S; Gimona, M; Rieder, G;
Cell Commun Signal. 2011; 9(1): 27
Full papers/articles (Journal)
Conference papers, proceedings, abstracts
Identification of early in vivo signalling signature during regenerative stem cell therapy using proteomic profiling
Rohban, R; Reinisch, A; Rohde, E; Hofmann, NA; Gimona, M; Etchart, N; Ortner, A; Strunk, D
BONE MARROW TRANSPL. 2011; 46: S50-S50.
Abstracts (Journal)
2010
Journal Articles
Candida albicans AGE3, the Ortholog of the S. cerevisiae ARF-GAP-Encoding Gene GCS1, Is Required for Hyphal Growth and Drug Resistance
Lettner, T; Zeidler, U; Gimona, M; Hauser, M; Breitenbach, M; Bito, A
PLOS ONE. 2010; 5(8): e11993
Full papers/articles (Journal)
2009
Journal Articles
Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation.
Crimaldi, L; Courtneidge, SA; Gimona, M;
Exp Cell Res. 2009; 315(15): 2581-2592.
Full papers/articles (Journal)
Mechanics and dynamics of the cytoskeleton: a special issue stemming from the 2008 ECF Meeting/FEBS Workshop (Mechanics and Dynamics of the Cytoskeleton) in Potsdam, Germany.
Gimona, M;
Cell Motil Cytoskeleton. 2009; 66(10): 769-770.
Editorials
Mechanics and dynamics of the cytoskeleton: a special issue stemming from the 2008 ECF Meeting/ FEBS Workshop (Mechanics and Dynamics of the Cytoskeleton) in Potsdam, Germany.
Gimona, M;
Cell Motil Cytoskeleton. 2009; 66(11):-iii.
Editorials
2008
Journal Articles
Viva adhesion! A Mediterranean meeting on cell-matrix contacts and tissue invasion.
Buccione, R; Gimona, M; Linder, S;
Eur J Cell Biol. 2008; 87(8-9): 457-458.
Editorials
The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells.
Dougherty, GW; Jose, C; Gimona, M; Cutler, ML;
Eur J Cell Biol. 2008; 87(8-9): 721-734.
Full papers/articles (Journal)
Plectin deposition at podosome rings requires myosin contractility.
Gad, A; Lach, S; Crimaldi, L; Gimona, M;
Cell Motil Cytoskeleton. 2008; 65(8): 614-625.
Full papers/articles (Journal)
The microfilament system in the formation of invasive adhesions.
Gimona, M;
Semin Cancer Biol. 2008; 18(1): 23-34.
Reviews
An alternatively spliced exon links intermediate filaments to adhesions.
Gimona, M;
Biochem J. 2008; 409(3): e1-e2.
Notes
Dimerization of tropomyosins.
Gimona, M;
Adv Exp Med Biol. 2008; 644: 73-84.
Reviews
Assembly and biological role of podosomes and invadopodia.
Gimona, M; Buccione, R; Courtneidge, SA; Linder, S;
Curr Opin Cell Biol. 2008; 20(2): 235-241.
Reviews
Calponins: adaptable modular regulators of the actin cytoskeleton.
Rozenblum, GT; Gimona, M;
Int J Biochem Cell Biol. 2008; 40(10):1990-1995
Reviews
Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts.
Thompson, O; Kleino, I; Crimaldi, L; Gimona, M; Saksela, K; Winder, SJ;
PLoS One. 2008; 3(11):e3638
Full papers/articles (Journal)
Book chapters
Dimerization of Tropomyosins
Gimona, M;
In: Peter Gunning editors(s). Advances in Experimental Medicine and Biology Volume 644: Tropomyosin. 644: Springer; p. 304. (ISBN: 978-0387857657 )
2007
Journal Articles
Implications on zinc binding to S100A2.
Koch, M; Bhattacharya, S; Kehl, T; Gimona, M; Vasák, M; Chazin, W; Heizmann, CW; Kroneck, PM; Fritz, G;
Biochim Biophys Acta. 2007; 1773(3):45-70
Full papers/articles (Journal)
UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
Yamashiro, S; Gimona, M; Ono, S;
J Cell Sci. 2007; 120(Pt 17):3022-3033
Full papers/articles (Journal)
2006
Journal Articles
Protein linguistics - a grammar for modular protein assembly?
Gimona, M;
Nat Rev Mol Cell Biol. 2006; 7(1): 68-73.
Reviews
Adhesions that mediate invasion.
Gimona, M; Buccione, R;
Int J Biochem Cell Biol. 2006; 38(11): 1875-1892.
Reviews
Matrix-degrading podosomes in smooth muscle cells.
Lener, T; Burgstaller, G; Crimaldi, L; Lach, S; Gimona, M;
Eur J Cell Biol. 2006; 85(3-4):183-189
Reviews
2005
Journal Articles
The actin cytoskeleton, RAS-cAMP signaling and mitochondrial ROS in yeast apoptosis.
Breitenbach, M; Laun, P; Gimona, M;
Trends Cell Biol. 2005; 15(12): 637-639.
Notes
Podosome-mediated matrix resorption and cell motility in vascular smooth muscle cells.
Burgstaller, G; Gimona, M;
Am J Physiol Heart Circ Physiol. 2005; 288(6): H3001-H3005.
Full papers/articles (Journal)
CLAMP, a novel microtubule-associated protein with EB-type calponin homology.
Dougherty, GW; Adler, HJ; Rzadzinska, A; Gimona, M; Tomita, Y; Lattig, MC; Merritt, RC; Kachar, B;
Cell Motil Cytoskeleton. 2005; 62(3): 141-156.
Full papers/articles (Journal)
Oktoberfest for adhesion structures.
Gimona, M; Grashoff, C; Kopp, P;
EMBO Rep. 2005; 6(10):922-926
keine Übereinstimmung
2004
Journal Articles
Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin.
Abouzaglou, J; Bénistant, C; Gimona, M; Roustan, C; Kassab, R; Fattoum, A;
Eur J Biochem. 2004; 271(13): 2615-2623.
Full papers/articles (Journal)
Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains.
Burgstaller, G; Gimona, M;
J Cell Sci. 2004; 117(Pt 2): 22-31.
Full papers/articles (Journal)
CRP2 is an autonomous actin-binding protein.
Grubinger, M; Gimona, M;
FEBS Lett. 2004; 557(1-3):88-92
Full papers/articles (Journal)
The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeats.
Lener, T; Burgstaller, G; Gimona, M;
FEBS Lett. 2004; 556(1-3):221-226
Full papers/articles (Journal)
Monographs ( scientific books)
Modular Protein Domains
Cesareni, G; Gimona, M; Sudol, M; Yaffe, M
Weinheim: WILEY VCH; 2004. pp. 502. (ISBN 978-3-527-30813-2)
Book chapters
The CH domain.
Gimona, M; Winder, SJ
In: Cesareni, G., Gimona, M., Sudol, M., Yaffe, M., (Eds.) editors(s). Modular Protein Domains.. Weinheim: WILEY VCH; (ISBN: 978-3-527-30813-2)
2003
Journal Articles
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.
Brandt, DT; Goerke, A; Heuer, M; Gimona, M; Leitges, M; Kremmer, E; Lammers, R; Haller, H; Mischak, H;
J Biol Chem. 2003; 278(36): 34073-34078.
Full papers/articles (Journal)
Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells.
Gimona, M; Kaverina, I; Resch, GP; Vignal, E; Burgstaller, G;
Mol Biol Cell. 2003; 14(6): 2482-2491.
Full papers/articles (Journal)
Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains.
Kaverina, I; Stradal, TE; Gimona, M;
J Cell Sci. 2003; 116(Pt 24):4915-4924
Full papers/articles (Journal)
2002
Journal Articles
Normalization of nomenclature for peptide motifs as ligands of modular protein domains.
Aasland, R; Abrams, C; Ampe, C; Ball, LJ; Bedford, MT; Cesareni, G; Gimona, M; Hurley, JH; Jarchau, T; Lehto, VP; Lemmon, MA; Linding, R; Mayer, BJ; Nagai, M; Sudol, M; Walter, U; Winder, SJ;
FEBS Lett. 2002; 513(1): 141-144.
Reviews
Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway.
Brandt, D; Gimona, M; Hillmann, M; Haller, H; Mischak, H;
J Biol Chem. 2002; 277(23): 20903-20910.
Full papers/articles (Journal)
The molecular basis for the autoregulation of calponin by isoform-specific C-terminal tail sequences.
Burgstaller, G; Kranewitter, WJ; Gimona, M;
J Cell Sci. 2002; 115(Pt 10): 2021-2029.
Full papers/articles (Journal)
Functional plasticity of CH domains.
Gimona, M; Djinovic-Carugo, K; Kranewitter, WJ; Winder, SJ;
FEBS Lett. 2002; 513(1): 98-106.
Reviews
Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells.
Hai, CM; Hahne, P; Harrington, EO; Gimona, M;
Exp Cell Res. 2002; 280(1): 64-74.
Full papers/articles (Journal)
2001
Journal Articles
GEF at work: Vav in protruding filopodia.
Kranewitter, WJ; Danninger, C; Gimona, M;
Cell Motil Cytoskeleton. 2001; 49(3): 154-160.
Full papers/articles (Journal)
UNC-87 is an actin-bundling protein.
Kranewitter, WJ; Ylanne, J; Gimona, M;
J Biol Chem. 2001; 276(9): 6306-6312.
Full papers/articles (Journal)
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions.
Rottner, K; Krause, M; Gimona, M; Small, JV; Wehland, J;
Mol Biol Cell. 2001; 12(10): 310-313.
Full papers/articles (Journal)
2000
Journal Articles
Live dynamics of GFP-calponin: isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences.
Danninger, C; Gimona, M;
J Cell Sci. 2000; 113 Pt 21: 3725-3736.
Full papers/articles (Journal)
Enforced polarisation and locomotion of fibroblasts lacking microtubules.
Kaverina, I; Krylyshkina, O; Gimona, M; Beningo, K; Wang, YL; Small, JV;
Curr Biol. 2000; 10(12): 739-742.
Full papers/articles (Journal)
Preliminary crystallographic study of turkey gizzard vinculin.
Kogan, O; Yarden, A; Gimona, M; Geiger, B; Safro, M;
Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 8): 1055-1057.
Notes
Mapping the zinc ligands of S100A2 by site-directed mutagenesis.
Stradal, TB; Troxler, H; Heizmann, CW; Gimona, M;
J Biol Chem. 2000; 275(18): 13219-13227.
Full papers/articles (Journal)
1999
Journal Articles
N-terminally truncated Vav induces the formation of depolymerization-resistant actin filaments in NIH 3T3 cells.
Kranewitter, WJ; Gimona, M;
FEBS Lett. 1999; 455(1-2): 123-129.
Full papers/articles (Journal)
Ca(2+)-dependent association of S100A6 (Calcyclin) with the plasma membrane and the nuclear envelope.
Stradal, TB; Gimona, M;
J Biol Chem. 1999; 274(44): 31593-31596.
Full papers/articles (Journal)
1998
Journal Articles
The single CH domain of calponin is neither sufficient nor necessary for F-actin binding.
Gimona, M; Mital, R;
J Cell Sci. 1998; 111 ( Pt 13): 1813-1821.
Full papers/articles (Journal)
Single calponin homology domains are not actin-binding domains.
Gimona, M; Winder, SJ;
Curr Biol. 1998; 8(19): R674-R675.
Letters
The cytoskeleton of the vertebrate smooth muscle cell.
Small, JV; Gimona, M;
Acta Physiol Scand. 1998; 164(4): 341-348.
Reviews
CH domains revisited.
Stradal, T; Kranewitter, W; Winder, SJ; Gimona, M;
FEBS Lett. 1998; 431(2): 134-137.
Notes
1997
Journal Articles
Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins.
Gimona, M; Lando, Z; Dolginov, Y; Vandekerckhove, J; Kobayashi, R; Sobieszek, A; Helfman, DM;
J Cell Sci. 1997; 110 ( Pt 5): 611-621.
Full papers/articles (Journal)
Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform.
Wehrens, XH; Mies, B; Gimona, M; Ramaekers, FC; Van Eys, GJ; Small, JV;
FEBS Lett. 1997; 405(3): 315-320.
Full papers/articles (Journal)
Book chapters
Calponin
Gimona, M; Small, JV
In: Sambrook and Tooze, Scientific Publishers
editors(s). Guidebook to the Cytoskeletal and Motor Proteins.
2nd edition. London: Oxford University Press, U.K.; p. 551. (ISBN: 978-0198599562 )
1996
Journal Articles
Expressing functional domains of mouse calponin: involvement of the region around alanine 145 in the actomyosin ATPase inhibitory activity of calponin.
el-Mezgueldi, M; Strasser, P; Fattoum, A; Gimona, M;
Biochemistry. 1996; 35(12):3654-3661
Full papers/articles (Journal)
Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.
Gimona, M; Kazzaz, JA; Helfman, DM;
Proc Natl Acad Sci U S A. 1996; 93(18): 9618-9623.
Full papers/articles (Journal)
Book chapters
Calponin
Gimona, M; Small, JV
In: M. Bárány ed. editors(s). Biochemistry of smooth muscle contraction. San Diego: Academic Press; p. 91-103. (ISBN: 978-0120781607 )
1995
Journal Articles
Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly.
Gimona, M; Watakabe, A; Helfman, DM;
Proc Natl Acad Sci U S A. 1995; 92(21): 9776-9780.
Full papers/articles (Journal)
Calponin reduces shortening velocity in skinned taenia coli smooth muscle fibres.
Jaworowski, A; Anderson, KI; Arner, A; Engström, M; Gimona, M; Strasser, P; Small, JV;
FEBS Lett. 1995; 365(2-3): 167-171.
Full papers/articles (Journal)
1994
Journal Articles
Beta-actin specific monoclonal antibody.
Gimona, M; Vandekerckhove, J; Goethals, M; Herzog, M; Lando, Z; Small, JV;
Cell Motil Cytoskeleton. 1994; 27(2): 108-116.
Full papers/articles (Journal)
Complex protein composition of isolated focal adhesions: a two-dimensional gel and database analysis.
Niederreiter, M; Gimona, M; Streichsbier, F; Celis, JE; Small, JV;
Electrophoresis. 1994; 15(3-4): 511-519.
Full papers/articles (Journal)
Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells.
North, AJ; Gimona, M; Cross, RA; Small, JV;
J Cell Sci. 1994; 107 ( Pt 3): 437-444.
Full papers/articles (Journal)
Actin isoform compartments in chicken gizzard smooth muscle cells.
North, AJ; Gimona, M; Lando, Z; Small, JV;
J Cell Sci. 1994; 107 ( Pt 3): 44-55.
Full papers/articles (Journal)
Isolation and functional reconstitution of a phosphate binding protein of the cyanobacterium Anacystis nidulans induced during phosphate-limited growth.
Wagner, F; Gimona, M; Ahorn, H; Peschek, GA; Falkner, G;
J Biol Chem. 1994; 269(8): 5509-5511.
Notes
Two domains of interaction with calcium binding proteins can be mapped using fragments of calponin.
Wills, FL; McCubbin, WD; Gimona, M; Strasser, P; Kay, CM;
Protein Sci. 1994; 3(12): 2311-2321.
Full papers/articles (Journal)
1993
Journal Articles
Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development.
Duband, JL; Gimona, M; Scatena, M; Sartore, S; Small, JV;
Differentiation. 1993; 55(1): 1-11.
Full papers/articles (Journal)
Evidence for a ternary interaction between alpha-actinin, (meta)vinculin and acidic-phospholipid bilayers.
Niggli, V; Gimona, M;
Eur J Biochem. 1993; 213(3): 1009-1015.
Full papers/articles (Journal)
Variable and constant regions in the C-terminus of vinculin and metavinculin. Cloning and expression of fragments in E. coli.
Strasser, P; Gimona, M; Herzog, M; Geiger, B; Small, JV;
FEBS Lett. 1993; 317(3): 189-194.
Full papers/articles (Journal)
Mammalian calponin. Identification and expression of genetic variants.
Strasser, P; Gimona, M; Moessler, H; Herzog, M; Small, JV;
FEBS Lett. 1993; 330(1):13-18
Full papers/articles (Journal)
1992
Journal Articles
Calponin and SM 22 isoforms in avian and mammalian smooth muscle. Absence of phosphorylation in vivo.
Gimona, M; Sparrow, MP; Strasser, P; Herzog, M; Small, JV;
Eur J Biochem. 1992; 205(3): 1067-1075.
Full papers/articles (Journal)
An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert.
Koteliansky, VE; Ogryzko, EP; Zhidkova, NI; Weller, PA; Critchley, DR; Vancompernolle, K; Vandekerckhove, J; Strasser, P; Way, M; Gimona, M;
Eur J Biochem. 1992; 204(2): 767-772.
Full papers/articles (Journal)
1991
Journal Articles
Calponin. Developmental isoforms and a low molecular weight variant.
Draeger, A; Gimona, M; Stuckert, A; Celis, JE; Small, JV;
FEBS Lett. 1991; 291(1): 24-28.
Full papers/articles (Journal)
1990
Journal Articles
Smooth muscle specific expression of calponin.
Gimona, M; Herzog, M; Vandekerckhove, J; Small, JV;
FEBS Lett. 1990; 274(1-2): 159-162.
Full papers/articles (Journal)
Isolation and sequence of a tropomyosin-binding fragment of turkey gizzard calponin.
Vancompernolle, K; Gimona, M; Herzog, M; Van Damme, J; Vandekerckhove, J; Small, V;
FEBS Lett. 1990; 274(1-2): 146-150.
Full papers/articles (Journal)
1988
Journal Articles
Porcine vinculin and metavinculin differ by a 68-residue insert located close to the carboxy-terminal part of the molecule.
Gimona, M; Small, JV; Moeremans, M; Van Damme, J; Puype, M; Vandekerckhove, J;
EMBO J. 1988; 7(8): 2329-2334.
Full papers/articles (Journal)
1987
Journal Articles
Metavinculin and vinculin from mammalian smooth muscle: bulk isolation and characterization.
Gimona, M; Fürst, DO; Small, JV;
J Muscle Res Cell Motil. 1987; 8(4): 329-341.
Full papers/articles (Journal)