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Forschungsdatenbank PMU-SQQUID

KOCHER THOMAS
Universitätsklinik für Dermatologie
Forschungsprogramm für Molekulare Therapie bei Genodermatosen

Publikationen | Forscherprofil

42 Publikationen

2019

Beiträge in Fachzeitschriften

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Rajan, N; Hofbauer, JP; Guttmann-Gruber, C; Bygum, A; Koller, U; Reichelt, J;
J Invest Dermatol. 2019;
Originalarbeiten (Zeitschrift)
An ex vivo RNA trans-splicing strategy to correct human generalized severe epidermolysis bullosa simplex.
Peking, P; Breitenbach, JS; Ablinger, M; Muss, WH; Poetschke, FJ; Kocher, T; Koller, U; Hainzl, S; Kitzmueller, S; Bauer, JW; Reichelt, J; Lettner, T; Wally, V;
Br J Dermatol. 2019; 180(1):141-148
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Gene editing as a therapeutic option for epidermolytic ichthyosis
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Aushev, M; Koller, U; Reichelt, J
EXP DERMATOL. 2019; 28(3): E45-E45.
Abstracts (Zeitschrift)

2018

Beiträge in Fachzeitschriften

ÖGDV Preisträger stellen sich vor: Der Österreichische Dermatologenpreis - Unilever Preis 2017 ging an Dr. Thomas Kocher aus Salzburg.
Kocher, T;
J Dtsch Dermatol Ges. 2018; 16(4): 529-531.
Kurzberichte/Notes
RNA Trans-Splicing Modulation via Antisense Molecule Interference.
Liemberger, B; Piñón Hofbauer, J; Wally, V; Arzt, C; Hainzl, S; Kocher, T; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U;
Int J Mol Sci. 2018; 19(3):
Originalarbeiten (Zeitschrift)

2017

Beiträge in Fachzeitschriften

COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa.
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; Del Rio, M; Duarte, B; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2573-2584
Originalarbeiten (Zeitschrift)
Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2585-2598
Originalarbeiten (Zeitschrift)
An RNA-targeted therapy for dystrophic epidermolysis bullosa.
Peking, P; Koller, U; Duarte, B; Murillas, R; Wolf, S; Maetzig, T; Rothe, M; Kocher, T; García, M; Brachtl, G; Schambach, A; Larcher, F; Reichelt, J; Bauer, JW; Murauer, EM;
Nucleic Acids Res. 2017; 45(17): 1025-10269.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Ex vivo COL7A1 editing via CRISPR/Cas9 in recessive dystrophic epidermolysis bullosa
Hainzl, S; Peking, P; Kocher, T; Murauer, E; Larcher, F; Duarte, B; Steiner, M; Bauer, J; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(5): S92-S92.
Abstracts (Zeitschrift)
CRISPR/Cas9 mediated gene correction of COL7A1
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; del Rio, M; Duarte, BG; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S224-S224.
Abstracts (Zeitschrift)
Improved safety profile: An efficient CRISPR/Cas9 double nicking approach for KRT14 repair in EB simplex
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S225-S225.
Abstracts (Zeitschrift)
Highly efficient and safe CRISPR/Cas9n double nicking-mediated KRT14 repair in epidermolysis bullosa simplex keratinocytes
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A57-A57.
Abstracts (Zeitschrift)
Antisense RNA-mediated improvement of SMaRT therapy for KRT14 correction
Liemberger, B; Arzt, C; Hainzl, S; Kocher, T; Hofbauer, JP; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S229-S229.
Abstracts (Zeitschrift)
Enhanced genome editing using split Staphylococcus aureus Cas9 delivered in self-complementary AAV vectors
Liemberger, B; Arzt, C; Hainzl, S; Wally, V; Kocher, T; Hofbauer, JP; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A63-A63.
Abstracts (Zeitschrift)
RNA trans-splicing-mediated COL7A1 repair in a dystrophic epidermolysis bullosa mouse model
Peking, P; Koller, U; Kocher, T; Nystroem, A; Reichelt, J; Bauer, JW; Murauer, EM
J INVEST DERMATOL. 2017; 137(10): S229-S229.
Abstracts (Zeitschrift)

2016

Beiträge in Fachzeitschriften

Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair.
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Neumayer, A; Reichelt, J; Bauer, JW; Koller, U
Int J Mol Sci. 2016; 17(10):
Originalarbeiten (Zeitschrift)
CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
Kocher, T; Asslaber, D; Zaborsky, N; Flenady, S; Denk, U; Reinthaler, P; Ablinger, M; Geisberger, R; Bauer, JW; Seiffert, M; Hartmann, TN; Greil, R; Egle, A; Piñón Hofbauer, J;
Leukemia. 2016; 30(6):1409-1413
Letter
A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair.
Peking, P; Koller, U; Hainzl, S; Kitzmueller, S; Kocher, T; Mayr, E; Nyström, A; Lener, T; Reichelt, J; Bauer, JW; Murauer, EM;
Mol Ther Nucleic Acids. 2016; 5: e287
Originalarbeiten (Zeitschrift)
Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations.
Tockner, B; Kocher, T; Hainzl, S; Reichelt, J; Bauer, JW; Koller, U; Murauer, EM;
Gene Ther. 2016; 23(11):775-784
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A murine transplantation model for trans-splicing corrected human keratinocytes
Ablinger, M; Breitenbach, JS; Lettner, T; Muss, W; Peking, P; Hainzl, S; Kocher, T; Kitzmuller, SK; Reichelt, J; Bauer, JW; Wally, V
HUM GENE THER. 2016; 27(11): A184-A184.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene correction of COL7A1 in dystrophic epidermolysis bullosa
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Koller, U
HUM GENE THER. 2016; 27(11): A144-A144.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene repair in the COL7A1 gene
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2016; 136(9): S189-S189.
Abstracts (Zeitschrift)

2015

Beiträge in Fachzeitschriften

Trans-splicing improvement by the combined application of antisense strategies.
Koller, U; Hainzl, S; Kocher, T; Hüttner, C; Klausegger, A; Gruber, C; Mayr, E; Wally, V; Bauer, JW; Murauer, EM;
Int J Mol Sci. 2015; 16(1):117-191
Originalarbeiten (Zeitschrift)
B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.
Zaborsky, N; Holler, C; Geisberger, R; Asslaber, D; Gassner, FJ; Egger, V; Piñón-Hofbauer, J; Kocher, T; Hartmann, TN; Greil, R; Egle, A;
Haematologica. 2015; 100(8):e307-e310
Letter

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Trans-splicing gene therapy in the KRT14 gene
Breitenbach, JS; Lettner, T; Kocher, T; Muss, W; Peking, P; Hainzl, S; Kitzmuller, SK; Ablinger, M; Potschke, FJ; Bauer, JW; Wally, V
HUM GENE THER. 2015; 26(10): A44-A44.
Abstracts (Zeitschrift)
The combined application of antisense-based strategies for RNA repair
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Bauer, JW; Koller, U
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)
A fluorescence-based screening system accelerates the design of RNA trans-splicing molecules for mRNA repair.
Kocher, T; Koller, U; Seyr, J; Hainzl, S; Mayer, E; Brachtl, G; Lener, T; Bauer, J; Wally, V; Murauer, E
J INVEST DERMATOL. 2015; 135: S60-S60.
Abstracts (Zeitschrift)
Analysis of binding characteristics of RNA trans-splicing molecules using a fluorescence-based screening system
Koller, U; Kocher, T; Seyr, J; Hainzl, S; Mayr, E; Tockner, B; Brachtl, G; Bauer, JW; Wally, V; Murauer, EM
EXP DERMATOL. 2015; 24(3): E16-E17.
Abstracts (Zeitschrift)
Correction of type VII collagen in a murine recessive dystrophic epidermolysis bullosa model using RNA trans-splicing
Peking, P; Koller, U; Hainzl, S; Kocher, T; Mayr, E; Kitzmuller, S; Lener, T; Bruckner-Tudermann, L; Bauer, JW; Murauer, EM
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)

2014

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Selection of antisense oligonucleotides for trans-splicing enhancement using a fluorescence-based screening system
Koller, U; Hainzl, S; Huttner, C; Kocher, T; Klausegger, A; Murauer, EM; Gruber, C; Mayr, E; Wally, V; Bauer, JW
J INVEST DERMATOL. 2014; 134: S61-S61.
Abstracts (Zeitschrift)
Correction of type VII collagen in dystrophic epidermolysis bullosa by novel trans-splicing molecules
Peking, P; Mayr, E; Koller, U; Hainzl, S; Kocher, T; Bauer, JW; Murauer, EM
J INVEST DERMATOL. 2014; 134: S56-S56.
Abstracts (Zeitschrift)

2013

Beiträge in Fachzeitschriften

The design and optimization of RNA trans-splicing molecules for skin cancer therapy.
Gruber, C; Koller, U; Murauer, EM; Hainzl, S; Huttner, C; Kocher, T; South, AP; Hintner, H; Bauer, JW
Mol Oncol. 2013; 7(6):105-168
Originalarbeiten (Zeitschrift)
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Lutzny, G; Kocher, T; Schmidt-Supprian, M; Rudelius, M; Klein-Hitpass, L; Finch, AJ; Dürig, J; Wagner, M; Haferlach, C; Kohlmann, A; Schnittger, S; Seifert, M; Wanninger, S; Zaborsky, N; Oostendorp, R; Ruland, J; Leitges, M; Kuhnt, T; Schäfer, Y; Lampl, B; Peschel, C; Egle, A; Ringshausen, I;
Cancer Cell. 2013; 23(1):77-92
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival
Asslaber, D; Hofbauer, JP; Zaborsky, N; Kocher, T; Hartmann, TN; Greil, R; Egle, A
ONKOLOGIE. 2013; 36: 222-223.
Abstracts (Zeitschrift)

2012

Beiträge in Fachzeitschriften

Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
Merkel, O; Wacht, N; Sifft, E; Melchardt, T; Hamacher, F; Kocher, T; Denk, U; Hofbauer, JP; Egle, A; Scheideler, M; Schlederer, M; Steurer, M; Kenner, L; Greil, R;
Leukemia. 2012; 26(12):2508-2516
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Protein Kinase C-beta Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B-Cells in Vivo
Lutzny, G; Kocher, T; Rudelius, M; Schmidt-Supprian, M; Klein-Hitpass, L; Durig, J; Oostendorp, RAJ; Peschel, C; Egle, A; Ringshausen, I
BLOOD. 2012; 120(21):
Abstracts (Zeitschrift)

2011

Beiträge in Fachzeitschriften

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.
Hofbauer, JP; Heyder, C; Denk, U; Kocher, T; Holler, C; Trapin, D; Asslaber, D; Tinhofer, I; Greil, R; Egle, A;
Leukemia. 2011; 25(9): 1452-1458.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

CLL CELLS INDUCE CLONAL T CELL SKEWING AND SUBSETSHIFTING IN THE MURINE TCL1 TRANSGENIC CHRONIC LYMPHOCYTIC LEUKEMIA MODEL
Egle, A; Pinon-Hofbauer, J; Heyder, C; Denk, U; Kocher, T; Holler, C; Trapin, D; Asslaber, D; Tinhofer, I; Greil, R
ANN ONCOL. 2011; 22: 144-144.
Abstracts (Zeitschrift)
Clonal Diversity of the T Cell Repertoire Predicts Disease Progression in Chronic Lymphocytic Leukaemia
Holler, C; Zaborsky, N; Hofbauer, JP; Kocher, T; Trapin, D; Asslaber, D; Greil, R; Egle, A
BLOOD. 2011; 118(21): 365-365.
Abstracts (Zeitschrift)
Tumor load reduction and prolongation of overall-survival by actinomycin D in a murine model of high-risk chronic lymphocytic leukemia
Wacht, N; Sifft, E; Melchardt, T; Hamacher, F; Denk, U; Pinon-Hofbauer, J; Egle, A; Kocher, T; Steurer, M; Greil, R; Merkel, O
ONKOLOGIE. 2011; 34: 141-141.
Abstracts (Zeitschrift)

2010

Beiträge in Fachzeitschriften

Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging.
Laimer, M; Kocher, T; Chiocchetti, A; Trost, A; Lottspeich, F; Richter, K; Hintner, H; Bauer, JW; Onder, K;
EXP DERMATOL. 2010; 19(10): 912-918.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Enzastaurin kills human CLL cells regardless of clinical risk profile, but fails to prolong life in a murine CLL model
Kocher, T; Pinon, HJ; Holler, C; Denk, U; Greil, R; Egle, A
ONKOLOGIE. 2010; 33: 40-40.
Abstracts (Zeitschrift)