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Forschungsdatenbank PMU-SQQUID

HAINZL STEFAN
Universitätsklinik für Dermatologie
Forschungsprogramm für Molekulare Therapie bei Genodermatosen

Publikationen | Forscherprofil

48 Publikationen

2019

Beiträge in Fachzeitschriften

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Rajan, N; Hofbauer, JP; Guttmann-Gruber, C; Bygum, A; Koller, U; Reichelt, J;
J Invest Dermatol. 2019;
Originalarbeiten (Zeitschrift)
An ex vivo RNA trans-splicing strategy to correct human generalized severe epidermolysis bullosa simplex.
Peking, P; Breitenbach, JS; Ablinger, M; Muss, WH; Poetschke, FJ; Kocher, T; Koller, U; Hainzl, S; Kitzmueller, S; Bauer, JW; Reichelt, J; Lettner, T; Wally, V;
Br J Dermatol. 2019; 180(1):141-148
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Gene editing as a therapeutic option for epidermolytic ichthyosis
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Aushev, M; Koller, U; Reichelt, J
EXP DERMATOL. 2019; 28(3): E45-E45.
Abstracts (Zeitschrift)

2018

Beiträge in Fachzeitschriften

ÖGDV Preisträger stellen sich vor: Der Wissenschaftspreis der ÖGDV 2017 ging an Dr. rer. nat. Stefan Hainzl und Dr. rer. nat. Patricia Peking aus Salzburg.
Hainzl, S; Peking, P;
J Dtsch Dermatol Ges. 2018; 16(4): 527-528.
Kurzberichte/Notes
RNA Trans-Splicing Modulation via Antisense Molecule Interference.
Liemberger, B; Piñón Hofbauer, J; Wally, V; Arzt, C; Hainzl, S; Kocher, T; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U;
Int J Mol Sci. 2018; 19(3):
Originalarbeiten (Zeitschrift)

2017

Beiträge in Fachzeitschriften

COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa.
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; Del Rio, M; Duarte, B; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2573-2584
Originalarbeiten (Zeitschrift)
A defect in the inner kinetochore protein CENPT causes a new syndrome of severe growth failure.
Hung, CY; Volkmar, B; Baker, JD; Bauer, JW; Gussoni, E; Hainzl, S; Klausegger, A; Lorenzo, J; Mihalek, I; Rittinger, O; Tekin, M; Dallman, JE; Bodamer, OA
PLOS ONE. 2017; 12(12): e0189324
Originalarbeiten (Zeitschrift)
Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2585-2598
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Ex vivo COL7A1 editing via CRISPR/Cas9 in recessive dystrophic epidermolysis bullosa
Hainzl, S; Peking, P; Kocher, T; Murauer, E; Larcher, F; Duarte, B; Steiner, M; Bauer, J; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(5): S92-S92.
Abstracts (Zeitschrift)
CRISPR/Cas9 mediated gene correction of COL7A1
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; del Rio, M; Duarte, BG; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S224-S224.
Abstracts (Zeitschrift)
Highly efficient and safe CRISPR/Cas9n double nicking-mediated KRT14 repair in epidermolysis bullosa simplex keratinocytes
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A57-A57.
Abstracts (Zeitschrift)
Improved safety profile: An efficient CRISPR/Cas9 double nicking approach for KRT14 repair in EB simplex
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S225-S225.
Abstracts (Zeitschrift)
Enhanced genome editing using split Staphylococcus aureus Cas9 delivered in self-complementary AAV vectors
Liemberger, B; Arzt, C; Hainzl, S; Wally, V; Kocher, T; Hofbauer, JP; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A63-A63.
Abstracts (Zeitschrift)

2016

Beiträge in Fachzeitschriften

Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair.
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Neumayer, A; Reichelt, J; Bauer, JW; Koller, U
Int J Mol Sci. 2016; 17(10):
Originalarbeiten (Zeitschrift)
A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair.
Peking, P; Koller, U; Hainzl, S; Kitzmueller, S; Kocher, T; Mayr, E; Nyström, A; Lener, T; Reichelt, J; Bauer, JW; Murauer, EM;
Mol Ther Nucleic Acids. 2016; 5: e287
Originalarbeiten (Zeitschrift)
Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations.
Tockner, B; Kocher, T; Hainzl, S; Reichelt, J; Bauer, JW; Koller, U; Murauer, EM;
Gene Ther. 2016; 23(11):775-784
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A murine transplantation model for trans-splicing corrected human keratinocytes
Ablinger, M; Breitenbach, JS; Lettner, T; Muss, W; Peking, P; Hainzl, S; Kocher, T; Kitzmuller, SK; Reichelt, J; Bauer, JW; Wally, V
HUM GENE THER. 2016; 27(11): A184-A184.
Abstracts (Zeitschrift)
Calcipotriol treatment increases low levels of cathelicidin expression and enhances anti-microbial activity of recessive dystrophic epidermolysis bullosa keratinocytes
Gruber, C; Hofbauer, JP; Tockner, B; Huttner, C; Breitenbach, JS; Trost, A; Leb-Reichl, VM; Klausegger, A; Hainzl, S; Reichelt, J; Bauer, JW; Lang, R
EXP DERMATOL. 2016; 25(3): E12-E12.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene correction of COL7A1 in dystrophic epidermolysis bullosa
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Koller, U
HUM GENE THER. 2016; 27(11): A144-A144.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene repair in the COL7A1 gene
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2016; 136(9): S189-S189.
Abstracts (Zeitschrift)
Combining antisense molecules with splicing modulation for KRT14 repair in epidermolysis bullosa
Liemberger, B; Arzt, C; Hainzl, S; Hofbauer, JP; Wally, V; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2016; 136(9): S189-S189.
Abstracts (Zeitschrift)
Antisense RNA-mediated improvement of SMaRT therapy for KRT14 correction
Liemberger, B; Arzt, C; Hainzl, S; Hofbauer, JP; Wally, V; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2016; 27(11): A135-A135.
Abstracts (Zeitschrift)

2015

Beiträge in Fachzeitschriften

Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.
Kazanis, I; Feichtner, M; Lange, S; Rotheneichner, P; Hainzl, S; Öller, M; Schallmoser, K; Rohde, E; Reitsamer, HA; Couillard-Despres, S; Bauer, HC; Franklin, RJ; Aigner, L; Rivera, FJ;
Exp Neurol. 2015; 269: 75-89.
Originalarbeiten (Zeitschrift)
Trans-splicing improvement by the combined application of antisense strategies.
Koller, U; Hainzl, S; Kocher, T; Hüttner, C; Klausegger, A; Gruber, C; Mayr, E; Wally, V; Bauer, JW; Murauer, EM;
Int J Mol Sci. 2015; 16(1):117-191
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Trans-splicing gene therapy in the KRT14 gene
Breitenbach, JS; Lettner, T; Kocher, T; Muss, W; Peking, P; Hainzl, S; Kitzmuller, SK; Ablinger, M; Potschke, FJ; Bauer, JW; Wally, V
HUM GENE THER. 2015; 26(10): A44-A44.
Abstracts (Zeitschrift)
The design and analysis of double RNA trans-splicing molecules for COL7A1 repair
Huttner, C; Hainzl, S; Murauer, EM; Bauer, JW; Koller, U
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)
The combined application of antisense-based strategies for RNA repair
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Bauer, JW; Koller, U
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)
A fluorescence-based screening system accelerates the design of RNA trans-splicing molecules for mRNA repair.
Kocher, T; Koller, U; Seyr, J; Hainzl, S; Mayer, E; Brachtl, G; Lener, T; Bauer, J; Wally, V; Murauer, E
J INVEST DERMATOL. 2015; 135: S60-S60.
Abstracts (Zeitschrift)
Analysis of binding characteristics of RNA trans-splicing molecules using a fluorescence-based screening system
Koller, U; Kocher, T; Seyr, J; Hainzl, S; Mayr, E; Tockner, B; Brachtl, G; Bauer, JW; Wally, V; Murauer, EM
EXP DERMATOL. 2015; 24(3): E16-E17.
Abstracts (Zeitschrift)
Pathological mechanisms underlying contracture formation in epidermolysis bullosa
Liemberger, B; Hainzl, S; Koller, U; Wally, V; Hofbauer, JP; Studnicka-Benke, A; Diem, A; Bauer, J; Breitenbach, J; Gruber, C
J INVEST DERMATOL. 2015; 135: S59-S59.
Abstracts (Zeitschrift)
Correction of type VII collagen in a murine recessive dystrophic epidermolysis bullosa model using RNA trans-splicing
Peking, P; Koller, U; Hainzl, S; Kocher, T; Mayr, E; Kitzmuller, S; Lener, T; Bruckner-Tudermann, L; Bauer, JW; Murauer, EM
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)

2014

Beiträge in Fachzeitschriften

Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.
Grössinger, EM; Weiss, L; Zierler, S; Rebhandl, S; Krenn, PW; Hinterseer, E; Schmölzer, J; Asslaber, D; Hainzl, S; Neureiter, D; Egle, A; Piñón-Hofbauer, J; Hartmann, TN; Greil, R; Kerschbaum, HH;
Leukemia. 2014; 28(4):954-958
Letter
AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells.
Huemer, M; Rebhandl, S; Zaborsky, N; Gassner, FJ; Hainzl, S; Weiss, L; Hebenstreit, D; Greil, R; Geisberger, R;
Eur J Immunol. 2014; 44(12):3747-3757
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Internal exon replacement as a promising tool for COL7A1 RNA repair
Huttner, C; Hainzl, S; Murauer, EM; Bauer, JW; Koller, U
J INVEST DERMATOL. 2014; 134: S58-S58.
Abstracts (Zeitschrift)
Selection of antisense oligonucleotides for trans-splicing enhancement using a fluorescence-based screening system
Koller, U; Hainzl, S; Huttner, C; Kocher, T; Klausegger, A; Murauer, EM; Gruber, C; Mayr, E; Wally, V; Bauer, JW
J INVEST DERMATOL. 2014; 134: S61-S61.
Abstracts (Zeitschrift)
Correction of type VII collagen in dystrophic epidermolysis bullosa by novel trans-splicing molecules
Peking, P; Mayr, E; Koller, U; Hainzl, S; Kocher, T; Bauer, JW; Murauer, EM
J INVEST DERMATOL. 2014; 134: S56-S56.
Abstracts (Zeitschrift)

2013

Beiträge in Fachzeitschriften

The design and optimization of RNA trans-splicing molecules for skin cancer therapy.
Gruber, C; Koller, U; Murauer, EM; Hainzl, S; Huttner, C; Kocher, T; South, AP; Hintner, H; Bauer, JW
Mol Oncol. 2013; 7(6):105-168
Originalarbeiten (Zeitschrift)
MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex.
Lettner, T; Lang, R; Klausegger, A; Hainzl, S; Bauer, JW; Wally, V;
PLoS One. 2013; 8(7):e70123
Originalarbeiten (Zeitschrift)
A reporter-based screen to identify potent 3" trans-splicing molecules for endogenous RNA repair.
Murauer, EM; Koller, U; Hainzl, S; Wally, V; Bauer, JW;
Hum Gene Ther Methods. 2013; 24(1):19-27
Originalarbeiten (Zeitschrift)
The pathogenetic role of IL-1β in severe epidermolysis bullosa simplex.
Wally, V; Lettner, T; Peking, P; Peckl-Schmid, D; Murauer, EM; Hainzl, S; Hintner, H; Bauer, JW;
J Invest Dermatol. 2013; 133(7):1901-1903
Letter

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

RNA trans-splicing molecules for targeted suicide gene delivery into cancer cells
Gruber, C; Koller, U; Hainzl, S; Murauer, EM; Huttner, C; South, AP; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2013; 133: S64-S64.
Abstracts (Zeitschrift)

2012

Beiträge in Fachzeitschriften

Dendritic cells activated by IFN-γ/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment.
Horejs-Hoeck, J; Schwarz, H; Lamprecht, S; Maier, E; Hainzl, S; Schmittner, M; Posselt, G; Stoecklinger, A; Hawranek, T; Duschl, A;
J IMMUNOL. 2012; 188(11): 5319-5326.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

IL-1beta as a therapeutic target in Epidermolysis bullosa simplex
Wally, V; Lettner, T; Klausegger, A; Hainzl, S; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2012; 132: S50-S50.
Abstracts (Zeitschrift)
Targeting IL-1 beta for the treatment of EBS-DM
Wally, V; Lettner, T; Peckl-Schmid, D; Klausegger, A; Hainzl, S; Hintner, H; Bauer, JW
EXP DERMATOL. 2012; 21(3): e6-e6.
Abstracts (Zeitschrift)

2011

Beiträge in Fachzeitschriften

IL-37: a new anti-inflammatory cytokine of the IL-1 family.
Boraschi, D; Lucchesi, D; Hainzl, S; Leitner, M; Maier, E; Mangelberger, D; Oostingh, GJ; Pfaller, T; Pixner, C; Posselt, G; Italiani, P; Nold, MF; Nold-Petry, CA; Bufler, P; Dinarello, CA;
EUR CYTOKINE NETW. 2011; 22(3): 12-47.
Übersichtsarbeiten
Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome.
Egger, M; Jurets, A; Wallner, M; Briza, P; Ruzek, S; Hainzl, S; Pichler, U; Kitzmuller, C; Bohle, B; Huber, CG; Ferreira, F
PLoS One. 2011; 6(2):e17278
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Screening for high efficient double RNA trans-splicing molecules to exchange a single exon of the COL17A1 gene
Koller, U; Wally, V; Mitchell, LG; Klausegger, A; Murauer, EM; Mayr, E; Gruber, C; Hainzl, S; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2011; 131: S67-S67.
Abstracts (Zeitschrift)

2010

Beiträge in Fachzeitschriften

K14 mRNA reprogramming for dominant epidermolysis bullosa simplex.
Wally, V; Brunner, M; Lettner, T; Wagner, M; Koller, U; Trost, A; Murauer, EM; Hainzl, S; Hintner, H; Bauer, JW;
Hum Mol Genet. 2010; 19(23):471-425
Originalarbeiten (Zeitschrift)