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Forschungsdatenbank PMU-SQQUID

LETTNER THOMAS
Universitätsklinik für Dermatologie
Forschungsprogramm für Molekulare Therapie bei Genodermatosen

Publikationen

31 Publikationen

2019

Beiträge in Fachzeitschriften

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Rajan, N; Hofbauer, JP; Guttmann-Gruber, C; Bygum, A; Koller, U; Reichelt, J;
J Invest Dermatol. 2019;
Originalarbeiten (Zeitschrift)
An ex vivo RNA trans-splicing strategy to correct human generalized severe epidermolysis bullosa simplex.
Peking, P; Breitenbach, JS; Ablinger, M; Muss, WH; Poetschke, FJ; Kocher, T; Koller, U; Hainzl, S; Kitzmueller, S; Bauer, JW; Reichelt, J; Lettner, T; Wally, V;
Br J Dermatol. 2019; 180(1):141-148
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Gene editing as a therapeutic option for epidermolytic ichthyosis
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Aushev, M; Koller, U; Reichelt, J
EXP DERMATOL. 2019; 28(3): E45-E45.
Abstracts (Zeitschrift)

2018

Beiträge in Fachzeitschriften

Basal pharmacokinetic parameters of topically applied diacerein in pediatric patients with generalized severe epidermolysis bullosa simplex.
Ablinger, M; Felder, TK; Wimmer, M; Zauner, R; Hofbauer, P; Lettner, T; Wolkersdorfer, M; Lagler, FB; Diem, A; Bauer, JW; Wally, V;
Orphanet J Rare Dis. 2018; 13(1): 193
Letter
Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability.
Sawant, M; Schwarz, N; Windoffer, R; Magin, TM; Krieger, J; Mücke, N; Obara, B; Jankowski, V; Jankowski, J; Wally, V; Lettner, T; Leube, RE;
J Invest Dermatol. 2018; 138(3):627-636
Originalarbeiten (Zeitschrift)
Diacerein orphan drug development for epidermolysis bullosa simplex: A phase 2/3 randomized, placebo-controlled, double-blind clinical trial.
Wally, V; Hovnanian, A; Ly, J; Buckova, H; Brunner, V; Lettner, T; Ablinger, M; Felder, TK; Hofbauer, P; Wolkersdorfer, M; Lagler, FB; Hitzl, W; Laimer, M; Kitzmüller, S; Diem, A; Bauer, JW;
J Am Acad Dermatol. 2018; 78(5): 892-901.e7.
Originalarbeiten (Zeitschrift)

2017

Beiträge in Fachzeitschriften

Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2585-2598
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Highly efficient and safe CRISPR/Cas9n double nicking-mediated KRT14 repair in epidermolysis bullosa simplex keratinocytes
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A57-A57.
Abstracts (Zeitschrift)
Improved safety profile: An efficient CRISPR/Cas9 double nicking approach for KRT14 repair in EB simplex
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S225-S225.
Abstracts (Zeitschrift)
Using a bivalent DNA aptamer to reduce blister formation in recessive dystrophic epidermolysis bullosa
Lettner, T; Reisenberger, M; Reitsamer, H; Bauer, JW; Reichelt, J; Wally, V
J INVEST DERMATOL. 2017; 137(10): S212-S212.
Abstracts (Zeitschrift)
Altering the splice pattern of COL17A1 with antisense oligonucleotides
Potocki, H; Lettner, T; Ablinger, M; Wimmer, M; Zauner, R; Friedl, N; Reichelt, J; Bauer, JW; Wally, V
J INVEST DERMATOL. 2017; 137(10): S227-S227.
Abstracts (Zeitschrift)
Deregulation of miR-10b affects HOXD10 expression in squamous cell carcinoma from epidermolysis bullosa patients
Wimmer, M; Zauner, R; Lettner, T; Niklas, N; Atzmuller, S; Reichelt, J; Bauer, JW; Wally, V
J INVEST DERMATOL. 2017; 137(10): S294-S294.
Abstracts (Zeitschrift)
Transcriptome profiling in recessive dystrophic epidermolysis bullosa patients
Zauner, R; Wimmer, M; Lettner, T; Gruber, C; Murauer, EM; Reichelt, J; Strunk, D; Bauer, JW; Wally, V
J INVEST DERMATOL. 2017; 137(10): S288-S288.
Abstracts (Zeitschrift)

2016

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A murine transplantation model for trans-splicing corrected human keratinocytes
Ablinger, M; Breitenbach, JS; Lettner, T; Muss, W; Peking, P; Hainzl, S; Kocher, T; Kitzmuller, SK; Reichelt, J; Bauer, JW; Wally, V
HUM GENE THER. 2016; 27(11): A184-A184.
Abstracts (Zeitschrift)
miRNA-10 as potential therapeutic target in recessive dystrophic epidermolysis bullosa
Wimmer, M; Zauner, R; Lettner, T; Niklas, N; Atzmuller, S; Reichelt, J; Bauer, JW; Wally, V
J INVEST DERMATOL. 2016; 136(9): S172-S172.
Abstracts (Zeitschrift)
miRNAs as potential players RDEB cancer development
Wimmer, M; Zauner, R; Lettner, T; Niklas, N; Proll, J; Bauer, JW; Reichelt, J; Wally, V
MELANOMA RES. 2016; 26: E70-E70.
Abstracts (Zeitschrift)
Micro RNAs as a disease modifier in recessive dystrophic epidermolysis bullosa
Wimmer, M; Zauner, R; Lettner, T; Niklas, N; Reichelt, J; Wally, V
EXP DERMATOL. 2016; 25(3): E14-E14.
Abstracts (Zeitschrift)
Identification of isomiRs in recessive dystrophic epidermolysis bullosa
Zauner, R; Wimmer, M; Lettner, T; Niklas, N; Atzmuller, S; Reichelt, J; Bauer, JW; Wally, V
J INVEST DERMATOL. 2016; 136(9): S187-S187.
Abstracts (Zeitschrift)
Identification of functional microRNA - mRNA regulatory modules in recessive dystrophic epidermolysis bullosa
Zauner, R; Wimmer, M; Lettner, T; Reichelt, J; Wally, V
EXP DERMATOL. 2016; 25(3): E15-E15.
Abstracts (Zeitschrift)

2015

Beiträge in Fachzeitschriften

Increased levels of matrix metalloproteinase-9 and interleukin-8 in blister fluids of dystrophic and junctional epidermolysis bullosa patients.
Lettner, T; Lang, R; Bauer, JW; Wally, V;
J Eur Acad Dermatol Venereol. 2015; 29(2): 396-398.
Letter

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Trans-splicing gene therapy in the KRT14 gene
Breitenbach, JS; Lettner, T; Kocher, T; Muss, W; Peking, P; Hainzl, S; Kitzmuller, SK; Ablinger, M; Potschke, FJ; Bauer, JW; Wally, V
HUM GENE THER. 2015; 26(10): A44-A44.
Abstracts (Zeitschrift)
Antisense Oligonucleotide therapy for the correction of COL17A1 splicing in junctional epidermolysis bullosa
Friedl, N; Lettner, T; Bauer, J; Wally, V
J INVEST DERMATOL. 2015; 135: S57-S57.
Abstracts (Zeitschrift)
Development of a luciferase reporter system for small molecule library screening with Dowling-Meara patient cell lines
Poetschke, FJ; Lettner, T; Bauer, J; Wally, V
J INVEST DERMATOL. 2015; 135: S58-S58.
Abstracts (Zeitschrift)
Micro-RNA signatures in recessive dystrophic epidermolysis bullosa
Zauner, R; Wimmer, M; Bauer, J; Lettner, T; Wally, V
J INVEST DERMATOL. 2015; 135: S61-S61.
Abstracts (Zeitschrift)

2013

Beiträge in Fachzeitschriften

MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex.
Lettner, T; Lang, R; Klausegger, A; Hainzl, S; Bauer, JW; Wally, V;
PLoS One. 2013; 8(7):e70123
Originalarbeiten (Zeitschrift)
The pathogenetic role of IL-1β in severe epidermolysis bullosa simplex.
Wally, V; Lettner, T; Peking, P; Peckl-Schmid, D; Murauer, EM; Hainzl, S; Hintner, H; Bauer, JW;
J Invest Dermatol. 2013; 133(7):1901-1903
Letter

2012

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Molecular pathomechanisms in Dowling-Meara type epidermolysis bullosa simplex cell lines
Lettner, T; Bauer, JW; Wally, V; Hintner, H
EXP DERMATOL. 2012; 21(3): e7-e7.
Abstracts (Zeitschrift)

2010

Beiträge in Fachzeitschriften

Candida albicans AGE3, the Ortholog of the S. cerevisiae ARF-GAP-Encoding Gene GCS1, Is Required for Hyphal Growth and Drug Resistance
Lettner, T; Zeidler, U; Gimona, M; Hauser, M; Breitenbach, M; Bito, A
PLOS ONE. 2010; 5(8): e11993
Originalarbeiten (Zeitschrift)
K14 mRNA reprogramming for dominant epidermolysis bullosa simplex.
Wally, V; Brunner, M; Lettner, T; Wagner, M; Koller, U; Trost, A; Murauer, EM; Hainzl, S; Hintner, H; Bauer, JW;
Hum Mol Genet. 2010; 19(23):471-425
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Keratin 14 mRNA trans-splicing in dominant Epidermolysis bullosa
Wally, V; Brunner, M; Lettner, T; Koller, U; Hintner, H; Bauer, JW
HUM GENE THER. 2010; 21(10): 1446-1446.
Abstracts (Zeitschrift)

2009

Beiträge in Fachzeitschriften

UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicans
Zeidler, U; Lettner, T; Lassnig, C; Muller, M; Lajko, R; Hintner, H; Breitenbach, M; Bito, A
FEMS YEAST RES. 2009; 9(1): 126-142.
Originalarbeiten (Zeitschrift)