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Forschungsdatenbank PMU-SQQUID

GUTTMANN-GRUBER CHRISTINA
Universitätsklinik für Dermatologie
Forschungsprogramm für Molekulare Therapie bei Genodermatosen

Publikationen | Forscherprofil

55 Publikationen

2019

Beiträge in Fachzeitschriften

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma.
Atanasova, VS; Pourreyron, C; Farshchian, M; Lawler, ME; Brown, CA; Watt, S; Wright, S; Warkala, M; Guttmann-Gruber, C; Pinon-Hofbauer, J; Fuentes, I; Prisco, M; Rashidghamat, E; Has, C; Salas-Alanis, JC; Palisson, F; Hovnanian, A; McGrath, JA; Mellerio, J; Bauer, JW; South, AP;
Clin Cancer Res. 2019; 25(11):3384-3391
Originalarbeiten (Zeitschrift)
Thrombospondin-1 Is a Major Activator of TGF-β Signaling in Recessive Dystrophic Epidermolysis Bullosa Fibroblasts.
Atanasova, VS; Russell, RJ; Webster, TG; Cao, Q; Agarwal, P; Lim, YZ; Krishnan, S; Fuentes, I; Guttmann-Gruber, C; McGrath, JA; Salas-Alanis, JC; Fertala, A; South, AP;
J Invest Dermatol. 2019; 139(7):1497-1505.e5
Originalarbeiten (Zeitschrift)
Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Rajan, N; Hofbauer, JP; Guttmann-Gruber, C; Bygum, A; Koller, U; Reichelt, J;
J Invest Dermatol. 2019;
Originalarbeiten (Zeitschrift)

2018

Beiträge in Fachzeitschriften

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.
Cho, RJ; Alexandrov, LB; den Breems, NY; Atanasova, VS; Farshchian, M; Purdom, E; Nguyen, TN; Coarfa, C; Rajapakshe, K; Prisco, M; Sahu, J; Tassone, P; Greenawalt, EJ; Collisson, EA; Wu, W; Yao, H; Su, XP; Guttmann-Gruber, C; Hofbauer, JP; Hashmi, R; Fuentes, I; Benz, SC; Golovato, J; Ehli, EA; Davis, CM; Davies, GE; Covington, KR; Murrell, DF; Salas-Alanis, JC; Palisson, F; Bruckner, AL; Robinson, W; Has, C; Bruckner-Tuderman, L; Titeux, M; Jonkman, MF; Rashidghamat, E; Lwin, SM; Mellerio, JE; McGrath, JA; Bauer, JW; Hovnanian, A; Tsai, KY; South, AP
SCI TRANSL MED. 2018; 10(455):
Originalarbeiten (Zeitschrift)
Reduced Microbial Diversity Is a Feature of Recessive Dystrophic Epidermolysis Bullosa-Involved Skin and Wounds.
Fuentes, I; Guttmann-Gruber, C; Ling Tay, AS; Hofbauer, JP; Denil, SLIJ; Reichelt, J; Palisson, F; Common, JEA; South, AP;
J Invest Dermatol. 2018; 138(11): 2492-2495.
Letter
Low-dose calcipotriol can elicit wound closure, anti-microbial, and anti-neoplastic effects in epidermolysis bullosa keratinocytes.
Guttmann-Gruber, C; Tockner, B; Scharler, C; Hüttner, C; Common, JE; Tay, ASL; Denil, SLIJ; Klausegger, A; Trost, A; Breitenbach, J; Schnitzhofer, P; Hofbauer, P; Wolkersdorfer, M; Diem, A; Laimer, M; Strunk, D; Bauer, JW; Reichelt, J; Lang, R; Piñón Hofbauer, J;
Sci Rep. 2018; 8(1): 13430
Originalarbeiten (Zeitschrift)
Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.
Morio, H; Sun, YC; Harada, M; Ide, H; Shimozato, O; Zhou, XJ; Higashi, K; Yuki, R; Yamaguchi, N; Hofbauer, JP; Guttmann-Gruber, C; Anzai, N; Akita, H; Chiba, K; Furihata, T
BIOL PHARM BULL. 2018; 41(3): 445-449.
Originalarbeiten (Zeitschrift)
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Sun, Y; Hofbauer, JP; Harada, M; Wöss, K; Koller, U; Morio, H; Stierschneider, A; Kitamura, K; Hashimoto, M; Chiba, K; Akita, H; Anzai, N; Reichelt, J; Bauer, JW; Guttmann-Gruber, C; Furihata, T;
Cancer Lett. 2018; 433: 107-116.
Originalarbeiten (Zeitschrift)
Extracellular Vesicles as Biomarkers for the Detection of a Tumor Marker Gene in Epidermolysis Bullosa-Associated Squamous Cell Carcinoma.
Sun, Y; Woess, K; Kienzl, M; Leb-Reichl, VM; Feinle, A; Wimmer, M; Zauner, R; Wally, V; Luetz-Meindl, U; Mellerio, JE; Fuentes, I; South, AP; Bauer, JW; Reichelt, J; Furihata, T; Guttmann-Gruber, C; Piñón Hofbauer, J;
J Invest Dermatol. 2018; 138(5):1197-1200
Letter

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Reduced microbial diversity is a feature of recessive dystrophic epidermolysis bullosa wounds
Fuentes, I; Guttmann-Gruber, C; Tay, ASSL; Common, JE; South, AP
J INVEST DERMATOL. 2018; 138(5): S126-S126.
Abstracts (Zeitschrift)
Cancer-type SLCO1B3 as a biomarker for epidermolysis bullosa-associated skin cancer
Guttmann-Gruber, C; Woss, K; Sun, Y; Furihata, T; Reichelt, J; Hofbauer, JP
J INVEST DERMATOL. 2018; 138(5): S38-S38.
Abstracts (Zeitschrift)
Metformin exerts anti-neoplastic effects against human and murine squamous cell carcinoma
Welponer, T; Trattner, L; Bauer, JW; Reichelt, J; Kofler, B; Hofbauer, JP; Guttmann-Gruber, C
J INVEST DERMATOL. 2018; 138(5): S84-S84.
Abstracts (Zeitschrift)

2017

Beiträge in Fachzeitschriften

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa
Atanasova, VS; Jiang, Q; Prisco, M; Gruber, C; Hofbauer, JP; Chen, M; Has, C; Bruckner-Tuderman, L; McGrath, JA; Uitto, J; South, AP
J INVEST DERMATOL. 2017; 137(9): 1842-1849.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Viral antigen-specific pre-vaccination prevents engraftment of tumor cells expressing the cognate antigen in mice
Leb-Reichl, V; Kienzl, M; Stoecklinger, A; Kitzmueller, S; Gratz, IK; Brachtl, G; Zaborsky, N; Reichelt, J; Gruber, C; Hofbauer, JP
J INVEST DERMATOL. 2017; 137(10): S286-S286.
Abstracts (Zeitschrift)
Extracellular vesicles as biomarkers for the detection of epidermolysis bullosa-associated squamous cell carcinoma
Sun, Y; Woess, K; Wimmer, M; Zauner, R; Feinle, A; Wally, V; South, A; Furihata, T; Hofbauer, JP; Gruber, C
J INVEST DERMATOL. 2017; 137(10): S288-S288.
Abstracts (Zeitschrift)
Transcriptome profiling in recessive dystrophic epidermolysis bullosa patients
Zauner, R; Wimmer, M; Lettner, T; Gruber, C; Murauer, EM; Reichelt, J; Strunk, D; Bauer, JW; Wally, V
J INVEST DERMATOL. 2017; 137(10): S288-S288.
Abstracts (Zeitschrift)

2016

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Efficacy and mechanism of amlexanox for potential treatment of recessive dystrophic epidermolysis bullosa
Atanasova, VS; Gruber, C; Chen, M; Uitto, J; South, A
J INVEST DERMATOL. 2016; 136(9): S187-S187.
Abstracts (Zeitschrift)
Calcipotriol treatment increases low levels of cathelicidin expression and enhances anti-microbial activity of recessive dystrophic epidermolysis bullosa keratinocytes
Gruber, C; Hofbauer, JP; Tockner, B; Huttner, C; Breitenbach, JS; Trost, A; Leb-Reichl, VM; Klausegger, A; Hainzl, S; Reichelt, J; Bauer, JW; Lang, R
EXP DERMATOL. 2016; 25(3): E12-E12.
Abstracts (Zeitschrift)
Calcipotriol enhances cathelicidin expression and improves bacterial defense and wound closure in epidermolysis bullosa
Gruber, C; Hofbauer, P; Tockner, B; Scharler, C; Huttner, C; Trost, A; Strunk, D; Bauer, JW; Reichelt, J; Lang, R
EXP DERMATOL. 2016; 25: 35-36.
Abstracts (Zeitschrift)
Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma
Kienzl, M; Leb-Reichl, V; Stoecklinger, A; Tockner, B; Gratz, IK; Bauer, JW; Reichelt, J; Gruber, C; Hofbauer, JP
J INVEST DERMATOL. 2016; 136(9): S242-S242.
Abstracts (Zeitschrift)
Rigosertib for the treatment of squamous cell carcinoma in recessive dystrophic epidermolysis bullosa
Pourreyron, C; Watt, SA; Wright, S; Gruber, C; Prisco, M; McGrath, JA; Mellerio, JE; Bauer, J; South, A
J INVEST DERMATOL. 2016; 136(5): S17-S17.
Abstracts (Zeitschrift)
Evaluation of the immunogenicity of viral epitopes in a cancer immunogene therapy approach for squamous cell carcinoma in RDEB
Reichl, VM; Kienzl, M; Stocklinger, A; Tockner, B; Reichelt, J; Gruber, C; Pinon-Hofbauer, J
MELANOMA RES. 2016; 26: E107-E107.
Abstracts (Zeitschrift)
Calcipotriol treatment enhances wound closure and antimicrobial defense in recessive dystrophic epidermolysis bullosa in vitro while inhibiting proliferation and clonogenicity of RDEB cancer cells.
Tockner, B; Scharler, C; Huttner, C; Zurl, A; Strunk, D; Bauer, JW; Reichelt, J; Lang, R; Gruber, C; Hofbauer, JP
MOL BIOL CELL. 2016; 27:
Abstracts (Zeitschrift)
Targeting tumor metabolism in the therapy of aggressive squamous cell carcinoma in patients with epidermolysis bullosa
Welponer, T; Hofbauer, JP; Gruber, C; Kienzl, M; Aminzadeh-Gohari, S; Feichtinger, R; Lang, R; Bauer, JW; Kofler, B; Reichelt, J
MELANOMA RES. 2016; 26: E77-E77.
Abstracts (Zeitschrift)

2015

Beiträge in Fachzeitschriften

Pseudosyndactyly - an inflammatory and fibrotic wound healing disorder in recessive dystrophic epidermolysis bullosa.
Boltzmann, L; Gruber, C; Klausegger, A; Trost, A; Bogner, B; Reitsamer, H; Bauer, JW;
J Dtsch Dermatol Ges. 2015; 13(12): 1257-1266.
Originalarbeiten (Zeitschrift)
Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging.
Breitenbach, JS; Rinnerthaler, M; Trost, A; Weber, M; Klausegger, A; Gruber, C; Bruckner, D; Reitsamer, HA; Bauer, JW; Breitenbach, M;
Aging (Albany NY). 2015; 7(6):389-411
Originalarbeiten (Zeitschrift)
Can we be SMaRT-er in our approach to cancer therapy?
Gruber, C; Hofbauer, JP; Bauer, JW;
EBioMedicine. 2015; 2(7): 621-622.
Kurzberichte/Notes
Trans-splicing improvement by the combined application of antisense strategies.
Koller, U; Hainzl, S; Kocher, T; Hüttner, C; Klausegger, A; Gruber, C; Mayr, E; Wally, V; Bauer, JW; Murauer, EM;
Int J Mol Sci. 2015; 16(1):117-191
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Pathological mechanisms underlying contracture formation in epidermolysis bullosa
Liemberger, B; Hainzl, S; Koller, U; Wally, V; Hofbauer, JP; Studnicka-Benke, A; Diem, A; Bauer, J; Breitenbach, J; Gruber, C
J INVEST DERMATOL. 2015; 135: S59-S59.
Abstracts (Zeitschrift)

2014

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Selection of antisense oligonucleotides for trans-splicing enhancement using a fluorescence-based screening system
Koller, U; Hainzl, S; Huttner, C; Kocher, T; Klausegger, A; Murauer, EM; Gruber, C; Mayr, E; Wally, V; Bauer, JW
J INVEST DERMATOL. 2014; 134: S61-S61.
Abstracts (Zeitschrift)

2013

Beiträge in Fachzeitschriften

The design and optimization of RNA trans-splicing molecules for skin cancer therapy.
Gruber, C; Koller, U; Murauer, EM; Hainzl, S; Huttner, C; Kocher, T; South, AP; Hintner, H; Bauer, JW
Mol Oncol. 2013; 7(6):105-168
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

RNA trans-splicing molecules for targeted suicide gene delivery into cancer cells
Gruber, C; Koller, U; Hainzl, S; Murauer, EM; Huttner, C; South, AP; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2013; 133: S64-S64.
Abstracts (Zeitschrift)

2012

Beiträge in Fachzeitschriften

Targeting of the hNC16A collagen domain to dendritic cells induces tolerance to human type XVII collagen.
Ettinger, M; Gratz, IK; Gruber, C; Hauser-Kronberger, C; Johnson, TS; Mahnke, K; Thalhamer, J; Hintner, H; Peckl-Schmid, D; Bauer, JW;
Exp Dermatol. 2012; 21(5):395-398
Letter
Transcutaneous gene gun delivery of hNC16A Induces BPAG2-specific tolerance.
Ettinger, M; Peckl-Schmid, D; Gruber, C; Laimer, M; Thalhamer, J; Hintner, H; Gratz, IK; Bauer, JW;
J INVEST DERMATOL. 2012; 132(6): 1665-1671.
Originalarbeiten (Zeitschrift)
Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression
Knaup, J; Verwanger, T; Gruber, C; Ziegler, V; Bauer, JW; Krammer, B
EXP DERMATOL. 2012; 21(7): 526-530.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Deciphering the mechanism of pseudosyndactyly in recessive dystrophic epidermolysis bullosa
Breitenbach, J; Gruber, C; Trost, A; Bogner, B; Hintner, H; Bauer, JW
EXP DERMATOL. 2012; 21(3): e19-e19.
Abstracts (Zeitschrift)
Gene gun treatment with NC16A prevents autoimmunity towards hBPAG2 in a skin grafting model
Ettinger, M; Peckl-Schmid, D; Gruber, C; Laimer, M; Thalhamer, J; Hintner, H; Gratz, IK; Bauer, JW
EXP DERMATOL. 2012; 21(3): e31-e31.
Abstracts (Zeitschrift)
Expression and regulation of cathelicidin in keratinocytes from patients with epidermolysis bullosa
Huttner, C; Gruber, C; Lang, R; Breitenbach, J; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2012; 132: S10-S10.
Abstracts (Zeitschrift)
Double RNA trans-splicing induced gene correction in epidermolysis bullosa
Koller, U; Hainzl, S; Klausegger, A; Wally, V; Murauer, EM; Mayr, E; Gruber, C; Mitchell, L; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2012; 132: S93-S93.
Abstracts (Zeitschrift)
Functional Correction of Mutations in COL7A1 in a RDEB Patient Cellline via 5 xxx trans-splicing
Mayr, E; Koller, U; Murauer, EM; Gruber, C; Kaiser, M; Klausegger, A; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2012; 132: S92-S92.
Abstracts (Zeitschrift)

2011

Beiträge in Fachzeitschriften

Spliceosome-mediated RNA trans-splicing facilitates targeted delivery of suicide genes to cancer cells.
Gruber, C; Gratz, IK; Murauer, EM; Mayr, E; Koller, U; Bruckner-Tuderman, L; Meneguzzi, G; Hintner, H; Bauer, JW;
Mol Cancer Ther. 2011; 10(2): 233-241.
Originalarbeiten (Zeitschrift)
TGFβ-signaling in squamous cell carcinoma occurring in recessive dystrophic epidermolysis bullosa.
Knaup, J; Gruber, C; Krammer, B; Ziegler, V; Bauer, J; Verwanger, T;
ANAL CELL PATHOL. 2011; 34(6): 339-353.
Originalarbeiten (Zeitschrift)
A novel screening system improves genetic correction by internal exon replacement.
Koller, U; Wally, V; Mitchell, LG; Klausegger, A; Murauer, EM; Mayr, E; Gruber, C; Hainzl, S; Hintner, H; Bauer, JW;
Nucleic Acids Res. 2011; 39(16): e108
Originalarbeiten (Zeitschrift)
Functional correction of type VII collagen expression in dystrophic epidermolysis bullosa.
Murauer, EM; Gache, Y; Gratz, IK; Klausegger, A; Muss, W; Gruber, C; Meneguzzi, G; Hintner, H; Bauer, JW;
J Invest Dermatol. 2011; 131(1):74-83
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Tolerance Induction towards Type XVII Collagen
Ettinger, M; Peckl-Schmid, D; Gratz, IK; Gruber, C; Johnson, TS; Mahnke, K; Hintner, H; Bauer, JW
EXP DERMATOL. 2011; 20(2): 177-177.
Abstracts (Zeitschrift)
Screening for high efficient double RNA trans-splicing molecules to exchange a single exon of the COL17A1 gene
Koller, U; Wally, V; Mitchell, LG; Klausegger, A; Murauer, EM; Mayr, E; Gruber, C; Hainzl, S; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2011; 131: S67-S67.
Abstracts (Zeitschrift)
A 5 xxx trans-splicing gene therapy approach for dystrophic epidermolysis bullosa
Mayr, E; Koller, U; Murauer, EM; Gruber, C; Klausegger, A; Kaiser, M; Bruckner-Tuderman, L; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2011; 131: S68-S68.
Abstracts (Zeitschrift)
Optimization of 3 xxx trans-splicing in the type VII Collagen gene
Tockner, B; Murauer, EM; Gruber, C; Mayr, E; Schlager, P; Wally, V; Koller, U; Klausegger, A; Hintner, H; Bauer, JW
HUM GENE THER. 2011; 22(10): A53-A53.
Abstracts (Zeitschrift)

2010

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

RNA trans-splicing technology facilitates targeted delivery of a suicide gene to cancer cells
Gruber, C; Gratz, IK; Mayr, E; Murauer, EM; Bruckner-Tuderman, L; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2010; 130: S79-S79.
Abstracts (Zeitschrift)
Improvement of RNA trans-splicing based gene correction using a RTM screening system
Koller, U; Wally, V; Mitchell, LG; Klausegger, A; Murauer, EM; Mayr, E; Gruber, C; Hintner, H; Bauer, JW
HUM GENE THER. 2010; 21(10): 1451-1451.
Abstracts (Zeitschrift)
Screening for the best 5 xxx pre-trans-splicing molecules in COL7A1 in order to develop a 5 xxx trans-splicing gene therapy approach for dystrophic Epidermolysis bullosa
Mayr, E; Koller, U; Murauer, EM; Gruber, C; Klausegger, A; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2010; 130: S80-S80.
Abstracts (Zeitschrift)

2009

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

In vitro Correction of COL7A1 Gene Mutations using RNA Trans-splicing
Murauer, EM; Gache, Y; Gratz, IK; Klausegger, A; Muss, W; Gruber, C; Meneguzzi, G; Hintner, H; Bauer, JW
J INVEST DERMATOL. 2009; 129: S45-S45.
Abstracts (Zeitschrift)

2007

Beiträge in Fachzeitschriften

Gene gun immunization with clinically relevant allergens aggravates allergen induced pathology and is contraindicated for allergen immunotherapy.
Scheiblhofer, S; Stoecklinger, A; Gruber, C; Hauser-Kronberger, C; Alinger, B; Hammerl, P; Thalhamer, J; Weiss, R;
MOL IMMUNOL. 2007; 44(8): 1879-1887.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

EB-associated squamous cell carcinoma (SCC): a profile of matrix metalloproteinases expression at the mRNA level
Gruber, C; Gratz, I; Volz, A; Bruckner-Tuderman, L; Meneguzzi, G; Bauer, JW
J INVEST DERMATOL. 2007; 127: S80-S80.
Abstracts (Zeitschrift)

2006

Beiträge in Fachzeitschriften

Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy.
Bauer, R; Scheiblhofer, S; Kern, K; Gruber, C; Stepanoska, T; Thalhamer, T; Hauser-Kronberger, C; Alinger, B; Zoegg, T; Gabler, M; Ferreira, F; Hartl, A; Thalhamer, J; Weiss, R;
J Allergy Clin Immunol. 2006; 118(1):269-276
Originalarbeiten (Zeitschrift)