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Forschungsdatenbank PMU-SQQUID

KOCHER THOMAS
Universitätsklinik für Dermatologie
Forschungsprogramm für Molekulare Therapie bei Genodermatosen

Publikationen | Forscherprofil

77 Publikationen

2022

Beiträge in Fachzeitschriften

Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa.
Bischof, J; March, OP; Liemberger, B; Haas, SA; Hainzl, S; Petković, I; Leb-Reichl, V; Illmer, J; Korotchenko, E; Klausegger, A; Hoog, A; Binder, HM; Garcia, M; Duarte, B; Strunk, D; Larcher, F; Reichelt, J; Guttmann-Gruber, C; Wally, V; Hofbauer, JP; Bauer, JW; Cathomen, T; Kocher, T; Koller, U;
Mol Ther. 2022; 30(8): 2680-2692.
Originalarbeiten (Zeitschrift)
Current developments in gene therapy for epidermolysis bullosa.
Kocher, T; Petkovic, I; Bischof, J; Koller, U;
Expert Opin Biol Ther. 2022; 22(9): 1137-1150.
Originalarbeiten (Zeitschrift)
COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa.
Petković, I; Bischof, J; Kocher, T; March, OP; Liemberger, B; Hainzl, S; Strunk, D; Raninger, AM; Binder, HM; Reichelt, J; Guttmann-Gruber, C; Wally, V; Piñón Hofbauer, J; Bauer, JW; Koller, U;
Front Med (Lausanne). 2022; 9: 976604
Originalarbeiten (Zeitschrift)
Evaluating a Targeted Cancer Therapy Approach Mediated by RNA trans-Splicing In Vitro and in a Xenograft Model for Epidermolysis Bullosa-Associated Skin Cancer
Woess, K; Sun, Y; Morio, H; Stierschneider, A; Kaufmann, A; Hainzl, S; Trattner, L; Kocher, T; Tockner, B; Leb-Reichl, V; Steiner, M; Brachtl, G; South, AP; Bauer, JW; Reichelt, J; Furihata, T; Wally, V; Koller, U; Piñón Hofbauer, J; Guttmann-Gruber, C;
Int J Mol Sci. 2022; 23(1):
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Efficient homology-directed repair CRISPR/Cas9-based gene editing in junctional epidermolysis bullosa keratinocytes
Petkovic, I; Bischof, J; Liemberger, B; March, OP; Reichelt, J; Binder, H; Strunk, D; Bauer, JW; Kocher, T; Koller, U
EXP DERMATOL. 2022; 31(2): E32-E32.
Abstracts (Zeitschrift)

2021

Beiträge in Fachzeitschriften

A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa
Kocher, T; Bischof, J; Haas, SA; March, OP; Liemberger, B; Hainzl, S; Illmer, J; Hoog, A; Muigg, K; Binder, HM; Klausegger, A; Strunk, D; Bauer, JW; Cathomen, T; Koller, U;
Mol Ther Nucleic Acids. 2021; 25: 237-250.
Originalarbeiten (Zeitschrift)
Advances in gene editing strategies for epidermolysis bullosa.
Kocher, T; Koller, U;
Prog Mol Biol Transl Sci. 2021; 182: 8-109.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Double-nicking-based correction of junctional epidermolysis bullosa via COL17A1 reframing
Bischof, J; March, OP; Haas, SA; Liemberger, B; Hainzl, S; Hoog, A; Binder, H; Duarte, B; Strunk, D; Larcher, F; Reichelt, J; Bauer, JW; Cathomen, T; Kocher, T; Koller, U
EXP DERMATOL. .. 2021; 30(3):E44-E44.
Abstracts (Zeitschrift)
CAST-Seq discloses low frequency of chromosomal rearrangements in double-nickase based genome editing in primary human cells
Klermund, J; Rhiel, M; Kocher, T; Bischof, J; Hainzl, S; Andrieux, G; el Gaz, M; Cornu, TI; Koller, U; Cathomen, T
HUM GENE THER. 2021; 32(19-20): A64-A64.
Abstracts (Zeitschrift)
Development of a non-invasive and non-viral in vivo RNA therapy approach for dystrophic epidermolysis bullosa
Liemberger, B; Kocher, T; Lettner, T; Ablinger, M; Reichl, V; Lackner, N; Peking, P; Murauer, EM; Nystrom, A; Wally, V; Mayr, E; Guttmann-Gruber, C; Bauer, JW; Koller, U
EXP DERMATOL. 2021; 30(3): E43-E43.
Abstracts (Zeitschrift)
COL17A1 editing in junctional epidermolysis bullosa keratinocytes via CRISPR/Cas9 induced homology-directed repair
Petkovic, I; Bischof, J; Liemberger, B; Kocher, T; March, OP; Reichelt, J; Binder, HM; Strunk, D; Bauer, JW; Koller, U
HUM GENE THER. 2021; 32(19-20): A65-A65.
Abstracts (Zeitschrift)
CRISPR/Cas9 nickase mediated gene therapy in primary keratinocytes derived from patients with EPPK
Trafoier, T; Hainzl, S; Kocher, T; Koller, U; Reichelt, J; Tiefenthaler, CH; Schmuth, M
J INVEST DERMATOL. 2021; 141(10): S175-S175.
Abstracts (Zeitschrift)

Beiträge in Sonstigen Zeitschriften

Gene-Editing-Strategien für Genodermatosen
Kocher, T; Koller, U;
Spectrum Dermatologie. 2021.

2020

Beiträge in Fachzeitschriften

Predictable CRISPR/Cas9-Mediated COL7A1 Reframing for Dystrophic Epidermolysis Bullosa.
Kocher, T; March, OP; Bischof, J; Liemberger, B; Hainzl, S; Klausegger, A; Hoog, A; Strunk, D; Bauer, JW; Koller, U;
J Invest Dermatol. 2020; 140(10):1985-1993.e5
Originalarbeiten (Zeitschrift)
Context-Dependent Strategies for Enhanced Genome Editing of Genodermatoses.
March, OP; Kocher, T; Koller, U;
Cells. 2020; 9(1):
Übersichtsarbeiten
A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas.
Wimmer, M; Zauner, R; Ablinger, M; Piñón-Hofbauer, J; Guttmann-Gruber, C; Reisenberger, M; Lettner, T; Niklas, N; Proell, J; Sajinovic, M; De Souza, P; Hainzl, S; Kocher, T; Murauer, EM; Bauer, JW; Strunk, D; Reichelt, J; Mellick, AS; Wally, V;
Cell Commun Signal. 2020; 18(1): 61
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

PAIRED SPCAS9 D10A RNPS PRODUCE THE SUBSTRATE FOR EFFICIENT GENE REPAIR VIA HOMOLOGOUS RECOMBINATION IN RDEB PATIENT KERATINONOCYTES
Kocher, T; Cathomen, T; Haas, S; Hoog, A; Strunk, D; Bauer, JW; Koller, U
ACTA DERM-VENEREOL. 2020; 100: 34-35.
Abstracts (Zeitschrift)
EXTRACELLULAR MATRIX DISTINCT SIGNATURE AMONG DYSTROPHIC EPIDERMOLYSIS BULLOSA VARIANTS
Malta, MD; Osorio, H; Guttmann-Gruber, C; Kocher, T; Carvalho, AF; Cerqueira, MT; Marques, AP
ACTA DERM-VENEREOL. 2020; 100: 54-54.
Abstracts (Zeitschrift)

Nichtpublizierte (nicht zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Paired SpCas9 D10A RNPs produce the substrate for efficient gene repair via homologous recombination in RDEB patient keratinocytes.
Kocher, T; Cathomen, T; Haas, S; Hoog, A; Strunk, D; Bauer, JW; Koller, U;
EB2020; 19.-23.01.2020; London. 2020.
A non-viral in vivo RNA therapy approach for dystrophic epidermolysis bullosa
Liemberger, Bernadette; Kocher, Thomas; Lackner, Nina; Peking, Patricia; Murauer, Eva M.; Mayr, Elisabeth; Guttmann-Gruber, Christina; Bauer, Johann W.; Koller, Ulrich;
ÖGDC Science Days 2020; 16.01 - 18.01.2020; Mondsee. 2020.
Paired nickase-mediated correction of junctional epidermolysis bullosa via COL17A1 reframing
March, O.; Bischof, J.; Kocher, T.; Liemberger, B.; Hainzl, S.; Haas, S.; Cathomen, T.; Hoog, A.; Strunk, D.; Reichelt, J.; Bauer, J. W.; Koller, u.;
ÖGDV Science Days ; 16.-18.01.2020; Schlosshotel Mondsee. 2020.
Paired SpCas9 D10A RNPs produce the substrate for efficient gene repair via homologous recombination in RDEB patient keratinocytes
Thomas Kocher / Toni Cathomen / Simone Haas / Anna Hoog / Dirk Strunk /Johann W Bauer / Ulrich Koller
2020; -EB2020; 19.01.-23.01.2020; London.

2019

Beiträge in Fachzeitschriften

Generation of rabbit polyclonal human and murine collagen VII monospecific antibodies: A useful tool for dystrophic epidermolysis bullosa therapy studies.
Bornert, O; Kocher, T; Gretzmeier, C; Liemberger, B; Hainzl, S; Koller, U; Nyström, A;
Matrix Biol Plus. 2019; 4:100017
Originalarbeiten (Zeitschrift)
Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination.
Kocher, T; Wagner, RN; Klausegger, A; Guttmann-Gruber, C; Hainzl, S; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther Nucleic Acids. 2019; 18:496-507
Originalarbeiten (Zeitschrift)
Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes.
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Rajan, N; Hofbauer, JP; Guttmann-Gruber, C; Bygum, A; Koller, U; Reichelt, J;
J Invest Dermatol. 2019; 139(8): 1699-1710.e6.
Originalarbeiten (Zeitschrift)
An ex vivo RNA trans-splicing strategy to correct human generalized severe epidermolysis bullosa simplex.
Peking, P; Breitenbach, JS; Ablinger, M; Muss, WH; Poetschke, FJ; Kocher, T; Koller, U; Hainzl, S; Kitzmueller, S; Bauer, JW; Reichelt, J; Lettner, T; Wally, V;
Br J Dermatol. 2019; 180(1):141-148
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A selection-free COL7A1 repair strategy based on homologous recombination
Kocher, T; Wagner, RN; Cathomen, T; Haas, S; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2019; 30(11): A177-A177.
Abstracts (Zeitschrift)
Highly efficient paired nickase-mediated correction of junctional epidermolysis bullosa via COL17A1 reframing
March, OP; Kocher, T; Liemberger, B; Bischof, J; Hainzl, S; Haas, S; Hochreiter, A; Strunk, D; Cathomen, T; Reichelt, J; Bauer, JW; Koller, U
HUM GENE THER. 2019; 30(11): A173-A173.
Abstracts (Zeitschrift)
Gene editing as a therapeutic option for epidermolytic ichthyosis
March, OP; Lettner, T; Klausegger, A; Ablinger, M; Kocher, T; Hainzl, S; Peking, P; Lackner, N; Aushev, M; Koller, U; Reichelt, J
EXP DERMATOL. 2019; 28(3): E45-E45.
Abstracts (Zeitschrift)

Nichtpublizierte (nicht zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A minicircle-based screening system facilitates the selection of promising CRISPR/Cas9 double nicking pairs for homology-directed repair of genetic mutations
Thomas Kocher, Roland Wagner, Alfred Klausegger, Johann Wolfgang Bauer, Julia Reichelt and Ulrich Koller
ÖGDV Science Days 2019; 10.01-12.01.2019; Schladming. 2019.

2018

Beiträge in Fachzeitschriften

ÖGDV Preisträger stellen sich vor: Der Österreichische Dermatologenpreis - Unilever Preis 2017 ging an Dr. Thomas Kocher aus Salzburg.
Kocher, T;
J Dtsch Dermatol Ges. 2018; 16(4): 529-531.
Kurzberichte/Notes
RNA Trans-Splicing Modulation via Antisense Molecule Interference.
Liemberger, B; Piñón Hofbauer, J; Wally, V; Arzt, C; Hainzl, S; Kocher, T; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U;
Int J Mol Sci. 2018; 19(3):
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Keratin 14 labelling with a fluorescence molecule facilitates efficiency analysis of RNA therapeutics in epidermolysis bullosa simplex
Kocher, T; Liemberger, B; Tischlinger, K; Steiner, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2018; 29(12): A95-A95.
Abstracts (Zeitschrift)
Keratin 14 labelling with a fluorescence molecule facilitates efficiency analysis of RNA therapeutics in epidermolysis bullosa simplex
Kocher, T; Liemberger, B; Tischlinger, K; Steiner, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2018; 29(12): A95-A95.
Abstracts (Zeitschrift)
A minicircle-based screening system facilitates the selection of promising CRISPR/Cas9 double nicking pairs for homology-directed repair of genetic mutations
Kocher, T; Wagner, R; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2018; 29(12): A105-A105.
Abstracts (Zeitschrift)
A minicircle-based screening system facilitates the selection of promising CRISPR/Cas9 double nicking pairs for homology-directed repair of genetic mutations
Kocher, T; Wagner, R; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2018; 29(12): A105-A105.
Abstracts (Zeitschrift)
TALEN-mediated inactivation of dominant-negative keratin alleles for general phenotypic alleviation of epidermolytic ichthyosis
March, OP; Kocher, T; Lackner, N; Hainzl, S; Lettner, T; Ablinger, M; Klausegger, A; Koller, U; Reichelt, J
HUM GENE THER. 2018; 29(12): A114-A114.
Abstracts (Zeitschrift)
TALEN-mediated inactivation of dominant-negative keratin alleles results in the formation of a stable functional cytoskeleton and phenotypic alleviation of epidermolytic ichthyosis
March, OP; Kocher, T; Lettner, T; Ablinger, M; Lackner, N; Hainzl, S; Peking, P; Aushev, M; Koller, U; Reichelt, J
J INVEST DERMATOL. 2018; 138(5): S138-S138.
Abstracts (Zeitschrift)

Nichtpublizierte (nicht zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Antisense RNA-mediated improvement of SMaRT therapy for KRT14 correction.
Bernadette Liemberger, Nina Lackner, Claudia Arzt, Stefan Hainzl, Verena Wally, Thomas Kocher, Josefina Piñón Hofbauer, Eva M. Murauer, Johann W. Bauer, Julia Reichelt, Ulrich Koller
2nd International Caparica Conference in Splicing; 16.-19.07.2018; Caparica. 2018.

2017

Beiträge in Fachzeitschriften

COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa.
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; Del Rio, M; Duarte, B; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2573-2584
Originalarbeiten (Zeitschrift)
Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U;
Mol Ther. 2017; 25(11):2585-2598
Originalarbeiten (Zeitschrift)
An RNA-targeted therapy for dystrophic epidermolysis bullosa.
Peking, P; Koller, U; Duarte, B; Murillas, R; Wolf, S; Maetzig, T; Rothe, M; Kocher, T; García, M; Brachtl, G; Schambach, A; Larcher, F; Reichelt, J; Bauer, JW; Murauer, EM;
Nucleic Acids Res. 2017; 45(17): 1025-10269.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Ex vivo COL7A1 editing via CRISPR/Cas9 in recessive dystrophic epidermolysis bullosa
Hainzl, S; Peking, P; Kocher, T; Murauer, E; Larcher, F; Duarte, B; Steiner, M; Bauer, J; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(5): S92-S92.
Abstracts (Zeitschrift)
CRISPR/Cas9 mediated gene correction of COL7A1
Hainzl, S; Peking, P; Kocher, T; Murauer, EM; Larcher, F; del Rio, M; Duarte, BG; Steiner, M; Klausegger, A; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S224-S224.
Abstracts (Zeitschrift)
Highly efficient and safe CRISPR/Cas9n double nicking-mediated KRT14 repair in epidermolysis bullosa simplex keratinocytes
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A57-A57.
Abstracts (Zeitschrift)
Improved safety profile: An efficient CRISPR/Cas9 double nicking approach for KRT14 repair in EB simplex
Kocher, T; Peking, P; Klausegger, A; Murauer, EM; Hofbauer, JP; Wally, V; Lettner, T; Hainzl, S; Ablinger, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S225-S225.
Abstracts (Zeitschrift)
Antisense RNA-mediated improvement of SMaRT therapy for KRT14 correction
Liemberger, B; Arzt, C; Hainzl, S; Kocher, T; Hofbauer, JP; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2017; 137(10): S229-S229.
Abstracts (Zeitschrift)
Enhanced genome editing using split Staphylococcus aureus Cas9 delivered in self-complementary AAV vectors
Liemberger, B; Arzt, C; Hainzl, S; Wally, V; Kocher, T; Hofbauer, JP; Murauer, EM; Bauer, JW; Reichelt, J; Koller, U
HUM GENE THER. 2017; 28(12): A63-A63.
Abstracts (Zeitschrift)
RNA trans-splicing-mediated COL7A1 repair in a dystrophic epidermolysis bullosa mouse model
Peking, P; Koller, U; Kocher, T; Nystroem, A; Reichelt, J; Bauer, JW; Murauer, EM
J INVEST DERMATOL. 2017; 137(10): S229-S229.
Abstracts (Zeitschrift)

2016

Beiträge in Fachzeitschriften

Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair.
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Neumayer, A; Reichelt, J; Bauer, JW; Koller, U
Int J Mol Sci. 2016; 17(10):
Originalarbeiten (Zeitschrift)
CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
Kocher, T; Asslaber, D; Zaborsky, N; Flenady, S; Denk, U; Reinthaler, P; Ablinger, M; Geisberger, R; Bauer, JW; Seiffert, M; Hartmann, TN; Greil, R; Egle, A; Piñón Hofbauer, J;
Leukemia. 2016; 30(6):1409-1413
Letter
A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair.
Peking, P; Koller, U; Hainzl, S; Kitzmueller, S; Kocher, T; Mayr, E; Nyström, A; Lener, T; Reichelt, J; Bauer, JW; Murauer, EM;
Mol Ther Nucleic Acids. 2016; 5: e287
Originalarbeiten (Zeitschrift)
Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations.
Tockner, B; Kocher, T; Hainzl, S; Reichelt, J; Bauer, JW; Koller, U; Murauer, EM;
Gene Ther. 2016; 23(11):775-784
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

A murine transplantation model for trans-splicing corrected human keratinocytes
Ablinger, M; Breitenbach, JS; Lettner, T; Muss, W; Peking, P; Hainzl, S; Kocher, T; Kitzmuller, SK; Reichelt, J; Bauer, JW; Wally, V
HUM GENE THER. 2016; 27(11): A184-A184.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene correction of COL7A1 in dystrophic epidermolysis bullosa
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Koller, U
HUM GENE THER. 2016; 27(11): A144-A144.
Abstracts (Zeitschrift)
CRISPR/Cas9-mediated gene repair in the COL7A1 gene
Hainzl, S; Kocher, T; Murauer, EM; Larcher, F; Steiner, M; Bauer, JW; Reichelt, J; Koller, U
J INVEST DERMATOL. 2016; 136(9): S189-S189.
Abstracts (Zeitschrift)

2015

Beiträge in Fachzeitschriften

Trans-splicing improvement by the combined application of antisense strategies.
Koller, U; Hainzl, S; Kocher, T; Hüttner, C; Klausegger, A; Gruber, C; Mayr, E; Wally, V; Bauer, JW; Murauer, EM;
Int J Mol Sci. 2015; 16(1):117-191
Originalarbeiten (Zeitschrift)
B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.
Zaborsky, N; Holler, C; Geisberger, R; Asslaber, D; Gassner, FJ; Egger, V; Piñón-Hofbauer, J; Kocher, T; Hartmann, TN; Greil, R; Egle, A;
Haematologica. 2015; 100(8):e307-e310
Letter

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Trans-splicing gene therapy in the KRT14 gene
Breitenbach, JS; Lettner, T; Kocher, T; Muss, W; Peking, P; Hainzl, S; Kitzmuller, SK; Ablinger, M; Potschke, FJ; Bauer, JW; Wally, V
HUM GENE THER. 2015; 26(10): A44-A44.
Abstracts (Zeitschrift)
The combined application of antisense-based strategies for RNA repair
Huttner, C; Murauer, EM; Hainzl, S; Kocher, T; Bauer, JW; Koller, U
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)
A fluorescence-based screening system accelerates the design of RNA trans-splicing molecules for mRNA repair.
Kocher, T; Koller, U; Seyr, J; Hainzl, S; Mayer, E; Brachtl, G; Lener, T; Bauer, J; Wally, V; Murauer, E
J INVEST DERMATOL. 2015; 135: S60-S60.
Abstracts (Zeitschrift)
Analysis of binding characteristics of RNA trans-splicing molecules using a fluorescence-based screening system
Koller, U; Kocher, T; Seyr, J; Hainzl, S; Mayr, E; Tockner, B; Brachtl, G; Bauer, JW; Wally, V; Murauer, EM
EXP DERMATOL. 2015; 24(3): E16-E17.
Abstracts (Zeitschrift)
Correction of type VII collagen in a murine recessive dystrophic epidermolysis bullosa model using RNA trans-splicing
Peking, P; Koller, U; Hainzl, S; Kocher, T; Mayr, E; Kitzmuller, S; Lener, T; Bruckner-Tudermann, L; Bauer, JW; Murauer, EM
HUM GENE THER. 2015; 26(10): A48-A48.
Abstracts (Zeitschrift)

2014

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Selection of antisense oligonucleotides for trans-splicing enhancement using a fluorescence-based screening system
Koller, U; Hainzl, S; Huttner, C; Kocher, T; Klausegger, A; Murauer, EM; Gruber, C; Mayr, E; Wally, V; Bauer, JW
J INVEST DERMATOL. 2014; 134: S61-S61.
Abstracts (Zeitschrift)
Correction of type VII collagen in dystrophic epidermolysis bullosa by novel trans-splicing molecules
Peking, P; Mayr, E; Koller, U; Hainzl, S; Kocher, T; Bauer, JW; Murauer, EM
J INVEST DERMATOL. 2014; 134: S56-S56.
Abstracts (Zeitschrift)

2013

Beiträge in Fachzeitschriften

The design and optimization of RNA trans-splicing molecules for skin cancer therapy.
Gruber, C; Koller, U; Murauer, EM; Hainzl, S; Huttner, C; Kocher, T; South, AP; Hintner, H; Bauer, JW
Mol Oncol. 2013; 7(6):105-168
Originalarbeiten (Zeitschrift)
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Lutzny, G; Kocher, T; Schmidt-Supprian, M; Rudelius, M; Klein-Hitpass, L; Finch, AJ; Dürig, J; Wagner, M; Haferlach, C; Kohlmann, A; Schnittger, S; Seifert, M; Wanninger, S; Zaborsky, N; Oostendorp, R; Ruland, J; Leitges, M; Kuhnt, T; Schäfer, Y; Lampl, B; Peschel, C; Egle, A; Ringshausen, I;
Cancer Cell. 2013; 23(1):77-92
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival
Asslaber, D; Hofbauer, JP; Zaborsky, N; Kocher, T; Hartmann, TN; Greil, R; Egle, A
ONKOLOGIE. 2013; 36: 222-223.
Abstracts (Zeitschrift)
A screening system accelerates the design of RNA trans-splicing molecules for skin cancer therapy
Koller, U; Gruber, C; Murauer, EM; Hainzl, S; Huttner, C; Kocher, T; South, AP; Hintner, H; Bauer, JW
HUM GENE THER. 2013; 24(12): A129-A129.
Abstracts (Zeitschrift)

2012

Beiträge in Fachzeitschriften

Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
Merkel, O; Wacht, N; Sifft, E; Melchardt, T; Hamacher, F; Kocher, T; Denk, U; Hofbauer, JP; Egle, A; Scheideler, M; Schlederer, M; Steurer, M; Kenner, L; Greil, R;
Leukemia. 2012; 26(12):2508-2516
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Protein Kinase C-beta Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B-Cells in Vivo
Lutzny, G; Kocher, T; Rudelius, M; Schmidt-Supprian, M; Klein-Hitpass, L; Durig, J; Oostendorp, RAJ; Peschel, C; Egle, A; Ringshausen, I
BLOOD. 2012; 120(21):
Abstracts (Zeitschrift)

2011

Beiträge in Fachzeitschriften

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.
Hofbauer, JP; Heyder, C; Denk, U; Kocher, T; Holler, C; Trapin, D; Asslaber, D; Tinhofer, I; Greil, R; Egle, A;
Leukemia. 2011; 25(9): 1452-1458.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

CLL CELLS INDUCE CLONAL T CELL SKEWING AND SUBSETSHIFTING IN THE MURINE TCL1 TRANSGENIC CHRONIC LYMPHOCYTIC LEUKEMIA MODEL
Egle, A; Pinon-Hofbauer, J; Heyder, C; Denk, U; Kocher, T; Holler, C; Trapin, D; Asslaber, D; Tinhofer, I; Greil, R
ANN ONCOL. 2011; 22: 144-144.
Abstracts (Zeitschrift)
Clonal Diversity of the T Cell Repertoire Predicts Disease Progression in Chronic Lymphocytic Leukaemia
Holler, C; Zaborsky, N; Hofbauer, JP; Kocher, T; Trapin, D; Asslaber, D; Greil, R; Egle, A
BLOOD. 2011; 118(21): 365-365.
Abstracts (Zeitschrift)
Tumor load reduction and prolongation of overall-survival by actinomycin D in a murine model of high-risk chronic lymphocytic leukemia
Wacht, N; Sifft, E; Melchardt, T; Hamacher, F; Denk, U; Pinon-Hofbauer, J; Egle, A; Kocher, T; Steurer, M; Greil, R; Merkel, O
ONKOLOGIE. 2011; 34: 141-141.
Abstracts (Zeitschrift)

2010

Beiträge in Fachzeitschriften

Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging.
Laimer, M; Kocher, T; Chiocchetti, A; Trost, A; Lottspeich, F; Richter, K; Hintner, H; Bauer, JW; Onder, K;
EXP DERMATOL. 2010; 19(10): 912-918.
Originalarbeiten (Zeitschrift)

Publizierte (zitierfähige) Beiträge für wissenschaftliche Veranstaltungen

Enzastaurin kills human CLL cells regardless of clinical risk profile, but fails to prolong life in a murine CLL model
Kocher, T; Pinon, HJ; Holler, C; Denk, U; Greil, R; Egle, A
ONKOLOGIE. 2010; 33: 40-40.
Abstracts (Zeitschrift)